| BUDINSKÁ, Eva, Jan GOJDA, Marie HECZKOVA, Miriam BRATOVA, Helena DANKOVA, Petr WOHL, Hana BASTOVA, Vera LANSKA, Martin KOSTOVCIK, Milan DASTYCH, Michal SENKYRIK, Jarmila KRIZOVA, Milos MRAZ, Jaromir HRADECKY, Jana HAJSLOVA, Martin LENICEK, Katerina PODZIMKOVA, Karel CHALUPSKY, Rastislav SEDLACEK a Monika CAHOVA. Microbiome and Metabolome Profiles Associated With Different Types of Short Bowel Syndrome: Implications for Treatment. Online. Journal of Parenteral and Enteral Nutrition. Hoboken: Wiley, 2020, roč. 44, č. 1, s. 105-118. ISSN 0148-6071. Dostupné z: https://dx.doi.org/10.1002/jpen.1595. [citováno 2024-04-23] |
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@article{1639276,
author = {Budinská, Eva and Gojda, Jan and Heczkova, Marie and Bratova, Miriam and Dankova, Helena and Wohl, Petr and Bastova, Hana and Lanska, Vera and Kostovcik, Martin and Dastych, Milan and Senkyrik, Michal and Krizova, Jarmila and Mraz, Milos and Hradecky, Jaromir and Hajslova, Jana and Lenicek, Martin and Podzimkova, Katerina and Chalupsky, Karel and Sedlacek, Rastislav and Cahova, Monika},
article_location = {Hoboken},
article_number = {1},
doi = {http://dx.doi.org/10.1002/jpen.1595},
keywords = {bile acids; gut microbiota; parenteral nutrition; short bowel syndrome; short-chain fatty acids; volatile organic compounds},
language = {eng},
issn = {0148-6071},
journal = {Journal of Parenteral and Enteral Nutrition},
title = {Microbiome and Metabolome Profiles Associated With Different Types of Short Bowel Syndrome: Implications for Treatment},
url = {https://doi.org/10.1002/jpen.1595},
volume = {44},
year = {2020}
}
TY - JOUR
ID - 1639276
AU - Budinská, Eva - Gojda, Jan - Heczkova, Marie - Bratova, Miriam - Dankova, Helena - Wohl, Petr - Bastova, Hana - Lanska, Vera - Kostovcik, Martin - Dastych, Milan - Senkyrik, Michal - Krizova, Jarmila - Mraz, Milos - Hradecky, Jaromir - Hajslova, Jana - Lenicek, Martin - Podzimkova, Katerina - Chalupsky, Karel - Sedlacek, Rastislav - Cahova, Monika
PY - 2020
TI - Microbiome and Metabolome Profiles Associated With Different Types of Short Bowel Syndrome: Implications for Treatment
JF - Journal of Parenteral and Enteral Nutrition
VL - 44
IS - 1
SP - 105-118
EP - 105-118
PB - Wiley
SN - 01486071
KW - bile acids
KW - gut microbiota
KW - parenteral nutrition
KW - short bowel syndrome
KW - short-chain fatty acids
KW - volatile organic compounds
UR - https://doi.org/10.1002/jpen.1595
L2 - https://doi.org/10.1002/jpen.1595
N2 - Background The gut microbiome and metabolome may significantly influence clinical outcomes in patients with short bowel syndrome (SBS). The study aimed to describe specific metagenomic/metabolomics profiles of different SBS types and to identify possible therapeutic targets. Methods Fecal microbiome (FM), volatile organic compounds (VOCs), and bile acid (BA) spectrum were analyzed in parenteral nutrition (PN)-dependent SBS I, SBS II, and PN-independent (non-PN) SBS patients. Results FM in SBS I, SBS II, and non-PN SBS shared characteristic features (depletion of beneficial anaerobes, high abundance of Lactobacilaceae and Enterobacteriaceae). SBS I patients were characterized by the abundance of oxygen-tolerant microrganisms and depletion of strict anaerobes. Non-PN SBS subjects showed markers of partial FM normalization. FM dysbiosis was translated into VOC and BA profiles characteristic for each SBS cohort. A typical signature of all SBS patients comprised high saturated aldehydes and medium-chain fatty acids and reduced short-chain fatty acid (SCFA) content. Particularly, SBS I and II exhibited low protein metabolism intermediate (indole, p-cresol) content despite the hypothetical presence of relevant metabolism pathways. Distinctive non-PN SBS marker was high phenol content. SBS patients' BA fecal spectrum was enriched by chenodeoxycholic and deoxycholic acids and depleted of lithocholic acid. Conclusions Environmental conditions in SBS gut significantly affect FM composition and metabolic activity. The common feature of diverse SBS subjects is the altered VOC/BA profile and the lack of important products of microbial metabolism. Strategies oriented on the microbiome/metabolome reconstitution and targeted delivery of key compounds may represent a promising therapeutic strategy in SBS patients.
ER -
BUDINSKÁ, Eva, Jan GOJDA, Marie HECZKOVA, Miriam BRATOVA, Helena DANKOVA, Petr WOHL, Hana BASTOVA, Vera LANSKA, Martin KOSTOVCIK, Milan DASTYCH, Michal SENKYRIK, Jarmila KRIZOVA, Milos MRAZ, Jaromir HRADECKY, Jana HAJSLOVA, Martin LENICEK, Katerina PODZIMKOVA, Karel CHALUPSKY, Rastislav SEDLACEK a Monika CAHOVA. Microbiome and Metabolome Profiles Associated With Different Types of Short Bowel Syndrome: Implications for Treatment. Online. \textit{Journal of Parenteral and Enteral Nutrition}. Hoboken: Wiley, 2020, roč.~44, č.~1, s.~105-118. ISSN~0148-6071. Dostupné z: https://dx.doi.org/10.1002/jpen.1595. [citováno 2024-04-23]
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