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@article{1639318,
author = {Komprda, Jiří and Komprdová, Klára and Dominguez Romero, Elena and Mikeš, Ondřej and Řiháčková, Katarína and Čupr, Pavel and Cerna, Milena and Scheringer, Martin},
article_location = {Amsterdam},
article_number = {NOV 2019},
doi = {http://dx.doi.org/10.1016/j.scitotenv.2019.06.504},
keywords = {Polychlorinated biphenyls; Intake; Human biomonitoring; Physiologically based pharmacokinetic (PBPK) model; Dietary exposure; Breast milk},
language = {eng},
issn = {0048-9697},
journal = {Science of the Total Environment},
title = {Dynamics of PCB exposure in the past 50 years and recent high concentrations in human breast milk: Analysis of influencing factors using a physiologically based pharmacokinetic model},
url = {http://dx.doi.org/10.1016/j.scitotenv.2019.06.504},
volume = {690},
year = {2019}
}
TY - JOUR
ID - 1639318
AU - Komprda, Jiří - Komprdová, Klára - Dominguez Romero, Elena - Mikeš, Ondřej - Řiháčková, Katarína - Čupr, Pavel - Cerna, Milena - Scheringer, Martin
PY - 2019
TI - Dynamics of PCB exposure in the past 50 years and recent high concentrations in human breast milk: Analysis of influencing factors using a physiologically based pharmacokinetic model
JF - Science of the Total Environment
VL - 690
IS - NOV 2019
SP - 388-399
EP - 388-399
PB - Elsevier Science
SN - 00489697
KW - Polychlorinated biphenyls
KW - Intake
KW - Human biomonitoring
KW - Physiologically based pharmacokinetic (PBPK) model
KW - Dietary exposure
KW - Breast milk
UR - http://dx.doi.org/10.1016/j.scitotenv.2019.06.504
L2 - http://dx.doi.org/10.1016/j.scitotenv.2019.06.504
N2 - In this study we reconstruct the long-term exposure of Czech mothers to polychlorinated biphenyls (PCBs) and determine the causes of high contamination of breast milk by indicator PCBs (iPCBs). A data set containing information from more than 1000 primiparous women from the Czech Republic was used, including iPCB concentrations in breast milk, individual physiology and living characteristics. The time series of PCB intakes for the whole period from the beginning of PCB production in 1958 until 2011 were reconstructed. We estimated the individual lifetime exposure of mothers for all iPCBs, i.e. congeners 28, 52, 101, 118, 138, 153 and 180. using a physiologically based pharmacokinetic (PBPK) model. Various model scenarios were investigated to determine the influence of physiology, age at delivery, past dietary exposure, and food composition on concentrations in breast milk for all iPCBs. The highest contributions to the presence of iPCBs in breast milk were observed for food composition. The main factor determining the concentration of higher-chlorinated PCBs (138, 153 and 180) was past exposure. The most important parameter for identification of children's postnatal exposure through breast milk was the time-span from the maximum of the exposure peak to the birth of the child. The current concentrations of iPCBs in breast milk in the Czech population are still high because the maximum of the exposure peak occurred more than 10 years later than in other European countries and was very broad, e.g. covered more than 10 years. (C) 2019 Elsevier B.V. All rights reserved.
ER -
KOMPRDA, Jiří, Klára KOMPRDOVÁ, Elena DOMINGUEZ ROMERO, Ondřej MIKEŠ, Katarína ŘIHÁČKOVÁ, Pavel ČUPR, Milena CERNA and Martin SCHERINGER. Dynamics of PCB exposure in the past 50 years and recent high concentrations in human breast milk: Analysis of influencing factors using a physiologically based pharmacokinetic model. \textit{Science of the Total Environment}. Amsterdam: Elsevier Science, 2019, vol.~690, NOV 2019, p.~388-399. ISSN~0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2019.06.504.
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