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@inproceedings{1640227,
author = {Labounek, René and Valosek, J. and Zimolka, J. and Piskorova, Z. and Horák, Tomáš and Svátková, Alena and Bednařík, Petr and Hok, P. and Vojtíšek, Lubomír and Hlustik, P. and Bednařík, Josef and Lenglet, C.},
address = {NEW YORK},
booktitle = {WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2018, VOL 1},
doi = {http://dx.doi.org/10.1007/978-981-10-9035-6_1},
keywords = {Diffusion MRI; HARDI; High-resolution imaging Cervical spinal cord},
howpublished = {elektronická verze "online"},
language = {eng},
location = {NEW YORK},
isbn = {978-981-10-9034-9},
pages = {3-7},
publisher = {SPRINGER},
title = {Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure},
year = {2019}
}
TY - JOUR
ID - 1640227
AU - Labounek, René - Valosek, J. - Zimolka, J. - Piskorova, Z. - Horák, Tomáš - Svátková, Alena - Bednařík, Petr - Hok, P. - Vojtíšek, Lubomír - Hlustik, P. - Bednařík, Josef - Lenglet, C.
PY - 2019
TI - Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure
PB - SPRINGER
CY - NEW YORK
SN - 9789811090349
KW - Diffusion MRI
KW - HARDI
KW - High-resolution imaging Cervical spinal cord
N2 - Diffusion Magnetic Resonance Imaging (dMRI) is a widely-utilized method for assessment of microstructural properties in the central nervous system i.e., the brain and spinal cord (SC). In the SC, almost all previous human studies utilized Diffusion Tensor Imaging (DTI), which cannot accurately model areas where white matter (WM) pathways cross or diverge. While High Angular Diffusion Resolution Imaging (HARDI) can overcome some of these limitations, longer acquisition times critically limit its applicability to clinical human studies. In addition, previous human HARDI studies have used limited spatial resolution, with typically a few slices and voxel size similar to 1 x 1 x 5 mm(3) being acquired in tens of minutes. Thus, we have optimized a novel fast HARDI protocol that allows collecting dMRI data at high angular and spatial resolutions in clinically-feasible time. Our data was acquired, using a 3T Siemens Prisma scanner, in less than 9 min. It has a total of 75 diffusion-weighted volumes and high spatial resolution of 0.67 x 0.67 x 3 mm(3) (after interpolation in Fourier space) covering the cervical segments C4-C6. Our preliminary results demonstrate applicability of our technique in healthy individuals with good correspondence between low fractional anisotropy (FA) gray matter areas from the dMRI scans, and the same regions delineated on T2-weighted MR images with spatial resolution of 0.35 x 0.35 x 2.5 mm(3). Our data also allows the detection of crossing fibers that were previously shown in vivo only in animal studies.
ER -
LABOUNEK, René, J. VALOSEK, J. ZIMOLKA, Z. PISKOROVA, Tomáš HORÁK, Alena SVÁTKOVÁ, Petr BEDNAŘÍK, P. HOK, Lubomír VOJTÍŠEK, P. HLUSTIK, Josef BEDNAŘÍK and C. LENGLET. Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure. Online. In \textit{WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2018, VOL 1}. NEW YORK: SPRINGER, 2019, p.~3-7. ISBN~978-981-10-9034-9. Available from: https://dx.doi.org/10.1007/978-981-10-9035-6\_{}1.
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