Fast In Vivo High-Resolution Diffusion MRI of the Human
Cervical Spinal Cord Microstructure

D 2019

Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure

LABOUNEK, René, J. VALOSEK, J. ZIMOLKA, Z. PISKOROVA, Tomáš HORÁK et. al.

Basic information

Original name

Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure

Authors

LABOUNEK, René (203 Czech Republic), J. VALOSEK, J. ZIMOLKA, Z. PISKOROVA, Tomáš HORÁK (203 Czech Republic, belonging to the institution), Alena SVÁTKOVÁ (703 Slovakia, belonging to the institution), Petr BEDNAŘÍK (203 Czech Republic, belonging to the institution), P. HOK, Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution), P. HLUSTIK, Josef BEDNAŘÍK (203 Czech Republic, guarantor, belonging to the institution) and C. LENGLET

Edition

NEW YORK, WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2018, VOL 1, p. 3-7, 5 pp. 2019

Publisher

SPRINGER

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

electronic version available online

RIV identification code

RIV/00216224:14740/19:00108610

Organization unit

Central European Institute of Technology

ISBN

978-981-10-9034-9

ISSN

DOI

http://dx.doi.org/10.1007/978-981-10-9035-6_1

UT WoS

000450908300001

Keywords in English

Diffusion MRI; HARDI; High-resolution imaging Cervical spinal cord

Abstract

V originále

Diffusion Magnetic Resonance Imaging (dMRI) is a widely-utilized method for assessment of microstructural properties in the central nervous system i.e., the brain and spinal cord (SC). In the SC, almost all previous human studies utilized Diffusion Tensor Imaging (DTI), which cannot accurately model areas where white matter (WM) pathways cross or diverge. While High Angular Diffusion Resolution Imaging (HARDI) can overcome some of these limitations, longer acquisition times critically limit its applicability to clinical human studies. In addition, previous human HARDI studies have used limited spatial resolution, with typically a few slices and voxel size similar to 1 x 1 x 5 mm(3) being acquired in tens of minutes. Thus, we have optimized a novel fast HARDI protocol that allows collecting dMRI data at high angular and spatial resolutions in clinically-feasible time. Our data was acquired, using a 3T Siemens Prisma scanner, in less than 9 min. It has a total of 75 diffusion-weighted volumes and high spatial resolution of 0.67 x 0.67 x 3 mm(3) (after interpolation in Fourier space) covering the cervical segments C4-C6. Our preliminary results demonstrate applicability of our technique in healthy individuals with good correspondence between low fractional anisotropy (FA) gray matter areas from the dMRI scans, and the same regions delineated on T2-weighted MR images with spatial resolution of 0.35 x 0.35 x 2.5 mm(3). Our data also allows the detection of crossing fibers that were previously shown in vivo only in animal studies.

Links

NV18-04-00159, research and development project

Name: Využití pokročilých magneticko-rezonančních technik k odhalení patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy

Investor: Ministry of Health of the CR

90062, large research infrastructures

Name: Czech-BioImaging

Citovat

LABOUNEK, René, J. VALOSEK, J. ZIMOLKA, Z. PISKOROVA, Tomáš HORÁK, Alena SVÁTKOVÁ, Petr BEDNAŘÍK, P. HOK, Lubomír VOJTÍŠEK, P. HLUSTIK, Josef BEDNAŘÍK and C. LENGLET. Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure. Online. In WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2018, VOL 1. NEW YORK: SPRINGER, 2019, p. 3-7. ISBN 978-981-10-9034-9. Available from: https://dx.doi.org/10.1007/978-981-10-9035-6_1.

@inproceedings{1640227,
   author = {Labounek, René and Valosek, J. and Zimolka, J. and Piskorova, Z. and Horák, Tomáš and Svátková, Alena and Bednařík, Petr and Hok, P. and Vojtíšek, Lubomír and Hlustik, P. and Bednařík, Josef and Lenglet, C.},
   address = {NEW YORK},
   booktitle = {WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2018, VOL 1},
   doi = {http://dx.doi.org/10.1007/978-981-10-9035-6_1},
   keywords = {Diffusion MRI; HARDI; High-resolution imaging Cervical spinal cord},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {NEW YORK},
   isbn = {978-981-10-9034-9},
   pages = {3-7},
   publisher = {SPRINGER},
   title = {Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure},
   year = {2019}
}

TY  - JOUR
ID  - 1640227
AU  - Labounek, René - Valosek, J. - Zimolka, J. - Piskorova, Z. - Horák, Tomáš - Svátková, Alena - Bednařík, Petr - Hok, P. - Vojtíšek, Lubomír - Hlustik, P. - Bednařík, Josef - Lenglet, C.
PY  - 2019
TI  - Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure
PB  - SPRINGER
CY  - NEW YORK
SN  - 9789811090349
KW  - Diffusion MRI
KW  - HARDI
KW  - High-resolution imaging Cervical spinal cord
N2  - Diffusion Magnetic Resonance Imaging (dMRI) is a widely-utilized method for assessment of microstructural properties in the central nervous system i.e., the brain and spinal cord (SC). In the SC, almost all previous human studies utilized Diffusion Tensor Imaging (DTI), which cannot accurately model areas where white matter (WM) pathways cross or diverge. While High Angular Diffusion Resolution Imaging (HARDI) can overcome some of these limitations, longer acquisition times critically limit its applicability to clinical human studies. In addition, previous human HARDI studies have used limited spatial resolution, with typically a few slices and voxel size similar to 1 x 1 x 5 mm(3) being acquired in tens of minutes. Thus, we have optimized a novel fast HARDI protocol that allows collecting dMRI data at high angular and spatial resolutions in clinically-feasible time. Our data was acquired, using a 3T Siemens Prisma scanner, in less than 9 min. It has a total of 75 diffusion-weighted volumes and high spatial resolution of 0.67 x 0.67 x 3 mm(3) (after interpolation in Fourier space) covering the cervical segments C4-C6. Our preliminary results demonstrate applicability of our technique in healthy individuals with good correspondence between low fractional anisotropy (FA) gray matter areas from the dMRI scans, and the same regions delineated on T2-weighted MR images with spatial resolution of 0.35 x 0.35 x 2.5 mm(3). Our data also allows the detection of crossing fibers that were previously shown in vivo only in animal studies.
ER  -

LABOUNEK, René, J. VALOSEK, J. ZIMOLKA, Z. PISKOROVA, Tomáš HORÁK, Alena SVÁTKOVÁ, Petr BEDNAŘÍK, P. HOK, Lubomír VOJTÍŠEK, P. HLUSTIK, Josef BEDNAŘÍK and C. LENGLET. Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure. Online. In \textit{WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2018, VOL 1}. NEW YORK: SPRINGER, 2019, p.~3-7. ISBN~978-981-10-9034-9. Available from: https://dx.doi.org/10.1007/978-981-10-9035-6\_{}1.

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