Detailed Information on Publication Record
2019
Global analysis and validation of miRNA levels in cerebrospinal fluid of brain tumor patients
KOPKOVÁ, Alena, Jiří ŠÁNA, Marek VEČEŘA, Táňa MACHÁČKOVÁ, Pavel FADRUS et. al.Basic information
Original name
Global analysis and validation of miRNA levels in cerebrospinal fluid of brain tumor patients
Authors
KOPKOVÁ, Alena (203 Czech Republic, belonging to the institution), Jiří ŠÁNA (203 Czech Republic, belonging to the institution), Marek VEČEŘA (703 Slovakia, belonging to the institution), Táňa MACHÁČKOVÁ (203 Czech Republic, belonging to the institution), Pavel FADRUS (203 Czech Republic, belonging to the institution), Júlia BOHOŠOVÁ (703 Slovakia, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)
Edition
AACR Annual Meeting on Bioinformatics, Convergence Science, and Systems Biology, 2019
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
30204 Oncology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 9.727
RIV identification code
RIV/00216224:14740/19:00108211
Organization unit
Central European Institute of Technology
ISSN
UT WoS
000488129904327
Keywords in English
miRNA; brain tumor
Tags
Tags
International impact
Změněno: 3/4/2020 19:54, Mgr. Pavla Foltynová, Ph.D.
Abstract
V originále
Incidence rate of primary brain tumors and brain metastases counts yearly around 40 patients per 100 000 persons in the world and is still growing. Prognosis and therapy differs between brain tumor types and, therefore, accurate and early diagnosis might improve survival and life quality of patients. However, current diagnostic approaches are limited by localization and tissue heterogeneity of brain tumors. Cerebrospinal fluid (CSF) bathes central nervous system (CNS) and thus is supposed to reflect all pathological conditions. From this perspective, CSF looks as ideal source of diagnostic biomarkers of brain tumors. MicroRNAs, short non-coding RNAs involved in the pathogenesis of many cancers including brain tumors, might represent group of new biomarkers. In addition, dysregulated levels of brain tumor specific miRNAs have been already observed also in CSF. Following these facts, analysis of CSF miRNAs in brain tumor patients promises a new diagnostic approach enabling more accurate diagnosis.
Links
| GA17-17636S, research and development project |
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| LQ1601, research and development project |
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| NV18-03-00398, research and development project |
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