Dysregulated expression of lncRNAs in glioblastoma multiforme and their association with overall survival

VEČEŘA, Marek, Jan OPPELT, Lenka RADOVÁ, Radim LIPINA, S. REGULI, Martin SMRČKA, R. JANCALEK, M. FILIP, M. HERMANOVA, L. KREN, Jiří ŠÁNA, Alena KOPKOVÁ, Júlia BOHOŠOVÁ and Ondřej SLABÝ. Dysregulated expression of lncRNAs in glioblastoma multiforme and their association with overall survival. In Annual Meeting of the American-Association-for-Cancer-Research (AACR). 2019. Available from: https://dx.doi.org/10.1158/1538-7445.AM2019-3575.

Basic information

• Original name: Dysregulated expression of lncRNAs in glioblastoma multiforme and their association with overall survival
• Authors: VEČEŘA, Marek (703 Slovakia, belonging to the institution), Jan OPPELT (203 Czech Republic, belonging to the institution), Lenka RADOVÁ (203 Czech Republic, belonging to the institution), Radim LIPINA (203 Czech Republic, belonging to the institution), S. REGULI, Martin SMRČKA (203 Czech Republic, belonging to the institution), R. JANCALEK, M. FILIP, M. HERMANOVA, L. KREN, Jiří ŠÁNA (203 Czech Republic, belonging to the institution), Alena KOPKOVÁ (203 Czech Republic, belonging to the institution), Júlia BOHOŠOVÁ (703 Slovakia, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Annual Meeting of the American-Association-for-Cancer-Research (AACR), 2019.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30204 Oncology
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14740/19:00108217
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1158/1538-7445.AM2019-3575
• UT WoS: 000488279402481
• Keywords in English: lncRNAs; glioblastoma
• Tags: rivok
• Tags: International impact

Abstract

Glioblastoma multiforme (GBM) is the most frequent primary brain malignancy of astrocytic origin. The prognosis remains very poor with the median overall survival (OS) being between 12 and 16 months from diagnosis despite early use of conventional medical therapy. Identifying new therapeutic targets, as well as prognostic and predictive biomarkers for accurate stratification of patients is therefore of utmost importance. Long non-coding RNAs (lncRNAs) are regulators of gene expression having critical impact on both physiological processes and the molecular pathology of GBM, indicating their potential as biomarkers and therapeutic targets.

Links

• GA17-17636S, research and development project: Name: Identifikace nových prognostických markerů a terapeutických cílových molekul u sarkomu měkkých tkání

Investor: Czech Science Foundation

• LQ1601, research and development project: Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

• NV18-03-00398, research and development project: Name: Rozšíření současných prognostických skórovacích systémů u mozkových metastáz o mikroRNA profilování s cílem individualizace pooperační péče

Investor: Ministry of Health of the CR, Extension of established prognostic scores in brain metastases by microRNA profiling to tailor the post-operative personalized care