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@article{1641357,
author = {Sisolakova, Ivana and Hovancova, Jana and Orinakova, Renata and Oriňák, Andrej and Trnková, Libuše and Garcia, Daniel Rueda and Radonak, Jozef},
article_location = {SWITZERLAND},
article_number = {DEC 2019},
doi = {http://dx.doi.org/10.1016/j.bioelechem.2019.06.011},
keywords = {Insulin determination; Screen printed carbon electrodes; Polymer membrane; Nickel oxide nanoparticles; Chitosan},
language = {eng},
issn = {1567-5394},
journal = {Bioelectrochemistry},
title = {Influence of a polymer membrane on the electrochemical determination of insulin in nanomodified screen printed carbon electrodes},
url = {https://www.sciencedirect.com/science/article/pii/S1567539419302166},
volume = {130},
year = {2019}
}
TY - JOUR
ID - 1641357
AU - Sisolakova, Ivana - Hovancova, Jana - Orinakova, Renata - Oriňák, Andrej - Trnková, Libuše - Garcia, Daniel Rueda - Radonak, Jozef
PY - 2019
TI - Influence of a polymer membrane on the electrochemical determination of insulin in nanomodified screen printed carbon electrodes
JF - Bioelectrochemistry
VL - 130
IS - DEC 2019
SP - 1-11
EP - 1-11
PB - Elsevier
SN - 15675394
KW - Insulin determination
KW - Screen printed carbon electrodes
KW - Polymer membrane
KW - Nickel oxide nanoparticles
KW - Chitosan
UR - https://www.sciencedirect.com/science/article/pii/S1567539419302166
L2 - https://www.sciencedirect.com/science/article/pii/S1567539419302166
N2 - Diabetes mellitus can be considered one of the most widespread diseases globally. Hence, the diabetes research is currently focused on developing an effective, low-cost sensor having high stability and suitable analytical characteristics. Screen printed carbon electrodes (SPCEs) embody ideal candidates for insulin determination due to the small area of the working electrode eliminating the solution volume required for the given purpose. Modification of SPCEs by using nanoparticles resulted in an increase of the working electrode surface area and formation of a higher number of active species. The aim of this paper is to examine the impact of a chitosan membrane on the electrochemical determination of insulin on NiO nanoparticles (NiONPs) and multi-walled nanotube (MWCNTs) modified SPCE (NiONPs/MWCNTs/SPCE). This study is primarily conceived to compare the analytical characteristics and stability of NiONPs/chitosan-MWCNTs/SPCE and NiONPs/MWCNTs/SPCE. An electrode modified with chitosan displays a wider linear range, one of 0.25 mu M - 5 mu M (R-2 0.997); a lower limit of detection, 94 nM; a high sensitivity (0.021 mu A/mu M) and better stability than that of an electrode without chitosan. According to these characteristics, the polymer is considered a necessary compound of the electrochemical insulin sensor, improving the sensor's analytical characteristics.
ER -
SISOLAKOVA, Ivana, Jana HOVANCOVA, Renata ORINAKOVA, Andrej ORIŇÁK, Libuše TRNKOVÁ, Daniel Rueda GARCIA a Jozef RADONAK. Influence of a polymer membrane on the electrochemical determination of insulin in nanomodified screen printed carbon electrodes. \textit{Bioelectrochemistry}. SWITZERLAND: Elsevier, 2019, roč.~130, DEC 2019, s.~1-11. ISSN~1567-5394. Dostupné z: https://dx.doi.org/10.1016/j.bioelechem.2019.06.011.
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