ŘEHÁKOVÁ, Daniela, Tereza SOURALOVÁ and Irena KOUTNÁ. Clinical-Grade Human Pluripotent Stem Cells for Cell Therapy: Characterization Strategy. International Journal of Molecular Sciences. Basel: MDPI, 2020, vol. 21, No 7, p. 1-14. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms21072435. |
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@article{1641416, author = {Řeháková, Daniela and Souralová, Tereza and Koutná, Irena}, article_location = {Basel}, article_number = {7}, doi = {http://dx.doi.org/10.3390/ijms21072435}, keywords = {hPSCs; human pluripotent stem cells; characterization; hESC; human embryonic stem cells; hiPSC; human induced pluripotent stem cells; clinical; cGMP; cell therapy}, language = {eng}, issn = {1422-0067}, journal = {International Journal of Molecular Sciences}, title = {Clinical-Grade Human Pluripotent Stem Cells for Cell Therapy: Characterization Strategy}, url = {https://www.mdpi.com/1422-0067/21/7/2435}, volume = {21}, year = {2020} }
TY - JOUR ID - 1641416 AU - Řeháková, Daniela - Souralová, Tereza - Koutná, Irena PY - 2020 TI - Clinical-Grade Human Pluripotent Stem Cells for Cell Therapy: Characterization Strategy JF - International Journal of Molecular Sciences VL - 21 IS - 7 SP - 1-14 EP - 1-14 PB - MDPI SN - 14220067 KW - hPSCs KW - human pluripotent stem cells KW - characterization KW - hESC KW - human embryonic stem cells KW - hiPSC KW - human induced pluripotent stem cells KW - clinical KW - cGMP KW - cell therapy UR - https://www.mdpi.com/1422-0067/21/7/2435 L2 - https://www.mdpi.com/1422-0067/21/7/2435 N2 - Human pluripotent stem cells have the potential to change the way in which human diseases are cured. Clinical-grade human embryonic stem cells and human induced pluripotent stem cells have to be created according to current good manufacturing practices and regulations. Quality and safety must be of the highest importance when humans' lives are at stake. With the rising number of clinical trials, there is a need for a consensus on hPSCs characterization. Here, we summarize mandatory and ' for information only ' characterization methods with release criteria for the establishment of clinical-grade hPSC lines. ER -
ŘEHÁKOVÁ, Daniela, Tereza SOURALOVÁ and Irena KOUTNÁ. Clinical-Grade Human Pluripotent Stem Cells for Cell Therapy: Characterization Strategy. \textit{International Journal of Molecular Sciences}. Basel: MDPI, 2020, vol.~21, No~7, p.~1-14. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms21072435.
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