SIMEK, Matej, Martina HERMANNOVA, Daniela SMEJKALOVA, Tereza FOGLOVA, Karel SOUČEK, Lucia BINO and Vladimir VELEBNY. LC-MS/MS study of in vivo fate of hyaluronan polymeric micelles carrying doxorubicin. Carbohydrate Polymers. Oxford: ELSEVIER SCI LTD, 2019, vol. 209, APR 1 2019, p. 181-189. ISSN 0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2018.12.104. |
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@article{1642136, author = {Simek, Matej and Hermannova, Martina and Smejkalova, Daniela and Foglova, Tereza and Souček, Karel and Bino, Lucia and Velebny, Vladimir}, article_location = {Oxford}, article_number = {APR 1 2019}, doi = {http://dx.doi.org/10.1016/j.carbpol.2018.12.104}, keywords = {Hyaluronan; Doxorubicin; Polymeric micelles; Biodistribution; Pharmacokinetics}, language = {eng}, issn = {0144-8617}, journal = {Carbohydrate Polymers}, title = {LC-MS/MS study of in vivo fate of hyaluronan polymeric micelles carrying doxorubicin}, url = {https://www.sciencedirect.com/science/article/pii/S0144861718315492}, volume = {209}, year = {2019} }
TY - JOUR ID - 1642136 AU - Simek, Matej - Hermannova, Martina - Smejkalova, Daniela - Foglova, Tereza - Souček, Karel - Bino, Lucia - Velebny, Vladimir PY - 2019 TI - LC-MS/MS study of in vivo fate of hyaluronan polymeric micelles carrying doxorubicin JF - Carbohydrate Polymers VL - 209 IS - APR 1 2019 SP - 181-189 EP - 181-189 PB - ELSEVIER SCI LTD SN - 01448617 KW - Hyaluronan KW - Doxorubicin KW - Polymeric micelles KW - Biodistribution KW - Pharmacokinetics UR - https://www.sciencedirect.com/science/article/pii/S0144861718315492 L2 - https://www.sciencedirect.com/science/article/pii/S0144861718315492 N2 - A better understanding of in vivo behavior of nanocarriers is necessary for further improvement in their development. Here we present a novel approach, where both the matrix and the drug can be analyzed by LC-MS/MS after one sample handling. The developed method was applied for the comparison of pharmacokinetic profile of free and encapsulated doxorubicin (DOX) in oleyl hyaluronan (HA-C18:1) polymeric micelles. The results indicated that nanocarriers were rapidly dissociated upon in vivo administration. Despite this fact, the administration of encapsulated DOX led to its longer circulation time and enhanced tumor targeting. This effect was not observed injecting blank HA-C18:1 micelles followed by unencapsulated DOX. Biodistribution studies and molecular weight estimation of the carrier matrix indicated relatively high stability of HA-C18:1 ester bond in bloodstream and complete elimination of the derivative within 72 h. The proposed methodology provides a novel strategy to elucidate the pharmacokinetic behavior of polysaccharide-based drug delivery systems. ER -
SIMEK, Matej, Martina HERMANNOVA, Daniela SMEJKALOVA, Tereza FOGLOVA, Karel SOUČEK, Lucia BINO and Vladimir VELEBNY. LC-MS/MS study of in vivo fate of hyaluronan polymeric micelles carrying doxorubicin. \textit{Carbohydrate Polymers}. Oxford: ELSEVIER SCI LTD, 2019, vol.~209, APR 1 2019, p.~181-189. ISSN~0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2018.12.104.
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