Anterior thalamic deep brain stimulation in epilepsy and
persistent psychiatric side effects following discontinuation

J 2019

Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation

DOLEŽALOVÁ, Irena, Jonáš KUNST, Martin KOJAN, Jan CHRASTINA, Marek BALÁŽ et. al.

Basic information

Original name

Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation

Authors

DOLEŽALOVÁ, Irena (203 Czech Republic, belonging to the institution), Jonáš KUNST (203 Czech Republic, belonging to the institution), Martin KOJAN (703 Slovakia, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution), Marek BALÁŽ (703 Slovakia, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, guarantor, belonging to the institution)

Edition

Epilepsy and Behavior Reports, Netherlands, Elsevier BV, 2019, 2589-9864

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14110/19:00108623

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ebr.2019.100344

UT WoS

000566534900006

Keywords in English

Case report; Deep brain stimulation of the anterior nucleus of the thalamus

Abstract

V originále

We report a case of a patient with drug-resistant epilepsy treated with deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS). The patient developed psychiatric side effects (PSEs), namely irritability, hostility, aggressiveness, and paranoia, after implantation and stimulation initiation. The stimulation was discontinued and the PSEs were mitigated, but the patient did not return to her pre-implantation state, as documented by repeated psychiatric reports and hospitalizations. To our knowledge, this is the first report of a patient who developed long-term PSEs that did not disappear after stimulation discontinuation. We suppose that ANT-DBS caused a persistent perturbation of the thalamic neuronal networks that are responsible for long-term PSEs.

Links

NV19-04-00343, research and development project

Name: Predikce Efektu Stimulace u pacientů s Epilepsií (PRESEnCE) (Acronym: PRESEnCE)

Investor: Ministry of Health of the CR

Citovat

DOLEŽALOVÁ, Irena, Jonáš KUNST, Martin KOJAN, Jan CHRASTINA, Marek BALÁŽ and Milan BRÁZDIL. Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation. Epilepsy and Behavior Reports. Netherlands: Elsevier BV, 2019, vol. 12, No 2019, p. 1-3. ISSN 2589-9864. Available from: https://dx.doi.org/10.1016/j.ebr.2019.100344.

@article{1643319,
   author = {Doležalová, Irena and Kunst, Jonáš and Kojan, Martin and Chrastina, Jan and Baláž, Marek and Brázdil, Milan},
   article_location = {Netherlands},
   article_number = {2019},
   doi = {http://dx.doi.org/10.1016/j.ebr.2019.100344},
   keywords = {Case report; Deep brain stimulation of the anterior nucleus of the thalamus},
   language = {eng},
   issn = {2589-9864},
   journal = {Epilepsy and Behavior Reports},
   title = {Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation},
   url = {https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub},
   volume = {12},
   year = {2019}
}

TY  - JOUR
ID  - 1643319
AU  - Doležalová, Irena - Kunst, Jonáš - Kojan, Martin - Chrastina, Jan - Baláž, Marek - Brázdil, Milan
PY  - 2019
TI  - Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation
JF  - Epilepsy and Behavior Reports
VL  - 12
IS  - 2019
SP  - 1-3
EP  - 1-3
PB  - Elsevier BV
SN  - 25899864
KW  - Case report
KW  - Deep brain stimulation of the anterior nucleus of the thalamus
UR  - https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub
N2  - We report a case of a patient with drug-resistant epilepsy treated with deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS). The patient developed psychiatric side effects (PSEs), namely irritability, hostility, aggressiveness, and paranoia, after implantation and stimulation initiation. The stimulation was discontinued and the PSEs were mitigated, but the patient did not return to her pre-implantation state, as documented by repeated psychiatric reports and hospitalizations. To our knowledge, this is the first report of a patient who developed long-term PSEs that did not disappear after stimulation discontinuation. We suppose that ANT-DBS caused a persistent perturbation of the thalamic neuronal networks that are responsible for long-term PSEs.
ER  -

DOLEŽALOVÁ, Irena, Jonáš KUNST, Martin KOJAN, Jan CHRASTINA, Marek BALÁŽ and Milan BRÁZDIL. Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation. \textit{Epilepsy and Behavior Reports}. Netherlands: Elsevier BV, 2019, vol.~12, No~2019, p.~1-3. ISSN~2589-9864. Available from: https://dx.doi.org/10.1016/j.ebr.2019.100344.

Detailed Information on Publication Record