Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation

DOLEŽALOVÁ, Irena, Jonáš KUNST, Martin KOJAN, Jan CHRASTINA, Marek BALÁŽ and Milan BRÁZDIL. Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation. Epilepsy and Behavior Reports. Netherlands: Elsevier BV, 2019, vol. 12, No 2019, p. 1-3. ISSN 2589-9864. Available from: https://dx.doi.org/10.1016/j.ebr.2019.100344.

Basic information

• Original name: Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation
• Authors: DOLEŽALOVÁ, Irena (203 Czech Republic, belonging to the institution), Jonáš KUNST (203 Czech Republic, belonging to the institution), Martin KOJAN (703 Slovakia, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution), Marek BALÁŽ (703 Slovakia, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Epilepsy and Behavior Reports, Netherlands, Elsevier BV, 2019, 2589-9864.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30210 Clinical neurology
• Country of publisher: Netherlands
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• RIV identification code: RIV/00216224:14110/19:00108623
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.ebr.2019.100344
• UT WoS: 000566534900006
• Keywords in English: Case report; Deep brain stimulation of the anterior nucleus of the thalamus
• Tags: 14110127, 14110131, rivok
• Tags: International impact, Reviewed

Abstract

We report a case of a patient with drug-resistant epilepsy treated with deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS). The patient developed psychiatric side effects (PSEs), namely irritability, hostility, aggressiveness, and paranoia, after implantation and stimulation initiation. The stimulation was discontinued and the PSEs were mitigated, but the patient did not return to her pre-implantation state, as documented by repeated psychiatric reports and hospitalizations. To our knowledge, this is the first report of a patient who developed long-term PSEs that did not disappear after stimulation discontinuation. We suppose that ANT-DBS caused a persistent perturbation of the thalamic neuronal networks that are responsible for long-term PSEs.

Links

• NV19-04-00343, research and development project: Name: Predikce Efektu Stimulace u pacientů s Epilepsií (PRESEnCE) (Acronym: PRESEnCE)

Investor: Ministry of Health of the CR