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@article{1643319, author = {Doležalová, Irena and Kunst, Jonáš and Kojan, Martin and Chrastina, Jan and Baláž, Marek and Brázdil, Milan}, article_location = {Netherlands}, article_number = {2019}, doi = {http://dx.doi.org/10.1016/j.ebr.2019.100344}, keywords = {Case report; Deep brain stimulation of the anterior nucleus of the thalamus}, language = {eng}, issn = {2589-9864}, journal = {Epilepsy and Behavior Reports}, title = {Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation}, url = {https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub}, volume = {12}, year = {2019} }
TY - JOUR ID - 1643319 AU - Doležalová, Irena - Kunst, Jonáš - Kojan, Martin - Chrastina, Jan - Baláž, Marek - Brázdil, Milan PY - 2019 TI - Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation JF - Epilepsy and Behavior Reports VL - 12 IS - 2019 SP - 1-3 EP - 1-3 PB - Elsevier BV SN - 25899864 KW - Case report KW - Deep brain stimulation of the anterior nucleus of the thalamus UR - https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub L2 - https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub N2 - We report a case of a patient with drug-resistant epilepsy treated with deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS). The patient developed psychiatric side effects (PSEs), namely irritability, hostility, aggressiveness, and paranoia, after implantation and stimulation initiation. The stimulation was discontinued and the PSEs were mitigated, but the patient did not return to her pre-implantation state, as documented by repeated psychiatric reports and hospitalizations. To our knowledge, this is the first report of a patient who developed long-term PSEs that did not disappear after stimulation discontinuation. We suppose that ANT-DBS caused a persistent perturbation of the thalamic neuronal networks that are responsible for long-term PSEs. ER -
DOLEŽALOVÁ, Irena, Jonáš KUNST, Martin KOJAN, Jan CHRASTINA, Marek BALÁŽ and Milan BRÁZDIL. Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation. \textit{Epilepsy and Behavior Reports}. Netherlands: Elsevier BV, 2019, vol.~12, No~2019, p.~1-3. ISSN~2589-9864. Available from: https://dx.doi.org/10.1016/j.ebr.2019.100344.
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