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@article{1646780,
author = {Havránková, Eva and Čalkovská, Nikola and Padrtová, Tereza and Csöllei, Jozef and Opatřilová, Radka and Pazdera, Pavel},
article_location = {Basel},
article_number = {8},
doi = {http://dx.doi.org/10.3390/molecules25081787},
keywords = {s-triazine; 4-aminophenol; hydroxychalcone; hydroxystilbene; antioxidative activity; ABTS method},
language = {eng},
issn = {1420-3049},
journal = {Molecules},
title = {Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs},
url = {https://doi.org/10.3390/molecules25081787},
volume = {25},
year = {2020}
}
TY - JOUR
ID - 1646780
AU - Havránková, Eva - Čalkovská, Nikola - Padrtová, Tereza - Csöllei, Jozef - Opatřilová, Radka - Pazdera, Pavel
PY - 2020
TI - Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs
JF - Molecules
VL - 25
IS - 8
SP - 1-15
EP - 1-15
PB - MDPI
SN - 14203049
KW - s-triazine
KW - 4-aminophenol
KW - hydroxychalcone
KW - hydroxystilbene
KW - antioxidative activity
KW - ABTS method
UR - https://doi.org/10.3390/molecules25081787
L2 - https://doi.org/10.3390/molecules25081787
N2 - A series of 1,3,5-triazine analogues, incorporating aminobenzene sulfonamide, aminoalcohol/phenol, piperazine, chalcone, or stilbene structural motifs, were evaluated as potential antioxidants. The compounds were prepared by using step-by-step nucleophilic substitution of chlorine atoms in starting 2,4,6-trichloro-1,3,5-triazine. Reactions were catalyzed by Cu(I)-supported on a weakly acidic resin. The radical scavenging activity was determined in terms of %inhibition activity and EC50, using the ABTS method. Trolox and ascorbic acid (ASA) were used as standards. In the lowest concentration 1 * 10-4 M, the %inhibition activity values at 0 min were comparable with both standards at least for 10 compounds. After 60 min, compounds 5, 6, 13, and 25 showed nearly twice %inhibition (73.44-87.09%) in comparison with the standards (Trolox = 41.49%; ASA = 31.07%). Values of EC50 at 60 min (17.16-27.78 muM) were 5 times lower for compounds 5, 6, 13, and 25 than EC50 of both standards (trolox = 178.33 muM; ASA = 147.47 muM). Values of EC50 correlated with %inhibition activity. Based on these results, the presented 1,3,5-triazine analogues have a high potential in the treatment of illnesses caused or related to oxidative stress.
ER -
HAVRÁNKOVÁ, Eva, Nikola ČALKOVSKÁ, Tereza PADRTOVÁ, Jozef CSÖLLEI, Radka OPATŘILOVÁ and Pavel PAZDERA. Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs. \textit{Molecules}. Basel: MDPI, 2020, vol.~25, No~8, p.~1-15. ISSN~1420-3049. Available from: https://dx.doi.org/10.3390/molecules25081787.
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