Sophisticated synthesis of monosubstituted piperazines – from a batch reaction vessel to a flow (microwave) reactor

NĚMEČKOVÁ, Dana, Eva HAVRÁNKOVÁ, Jan ŠIMBERA, Richard ŠEVČÍK a Pavel PAZDERA. Sophisticated synthesis of monosubstituted piperazines – from a batch reaction vessel to a flow (microwave) reactor. In The 23rd International Electronic Conference on Synthetic Organic Chemistry. doi:10.3390/ecsoc-23-06478. 2019.

Základní údaje

• Originální název: Sophisticated synthesis of monosubstituted piperazines – from a batch reaction vessel to a flow (microwave) reactor
• Autoři: NĚMEČKOVÁ, Dana, Eva HAVRÁNKOVÁ, Jan ŠIMBERA, Richard ŠEVČÍK a Pavel PAZDERA.
• Vydání: The 23rd International Electronic Conference on Synthetic Organic Chemistry, 2019.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Prezentace na konferencích
• Obor: 10401 Organic chemistry
• Stát vydavatele: Švýcarsko
• Utajení: není předmětem státního či obchodního tajemství
• WWW: URL
• Organizační jednotka: Přírodovědecká fakulta
• Doi: http://dx.doi.org/10.3390/ecsoc-23-06478
• Klíčová slova anglicky: piperazine; monosubstituted; heterocyclic; catalysis; heterogeneous; microwave; synthesis, supported catalyst; reactor

Anotace

We report a novel sophisticated synthetic method for preparation of monosubstituted piperazine derivatives, which can now be easily prepared in a one-pot-one-step way from a free piperazine with no need of introduction of a protecting group bringing further disadvantages in terms of time, costs and reduced yields. Reactions proceeding either at room or higher temperatures in common solvents employ with advantage heterogeneous catalysis by metal ions supported on commercial polymeric resins. Further, we have picked up a set of piperazine derivatives and studied the possibilities of microwave acceleration of given synthetic reactions. Our investigation proceeded from a simple batch technique to the construction of a flow microwave reactor and resulted in promising findings which are summarized and discussed in our contribution.