J 2016

Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism (rs12762303) and arachidonate 5-lipoxygenase activating protein (ALOX5AP) gene polymorphism (rs3802278) and markers of carotid atherosclerosis in patients with type 2 diabetes mellitus

MERLO, S., M. S. LETONJA, A. C. VUJKOVAC, D. DELEV, I. MOZOS et. al.

Basic information

Original name

Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism (rs12762303) and arachidonate 5-lipoxygenase activating protein (ALOX5AP) gene polymorphism (rs3802278) and markers of carotid atherosclerosis in patients with type 2 diabetes mellitus

Authors

MERLO, S. (705 Slovenia), M. S. LETONJA (705 Slovenia), A. C. VUJKOVAC (705 Slovenia), D. DELEV (100 Bulgaria), I. MOZOS (642 Romania), Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution) and D. PETROVIC (705 Slovenia)

Edition

International Journal of Clinical and Experimental Medicine, Madison, e-Century Publishing Corporation, 2016, 1940-5901

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30230 Other clinical medicine subjects

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.069

RIV identification code

RIV/00216224:14110/16:00113808

Organization unit

Faculty of Medicine

UT WoS

000374655200490

Keywords in English

Arachidonate 5-lipoxygenase; arachidonate 5-lipoxygenase activating protein; genetic polymorphism; association study; carotid atherosclerosis; type 2 diabetes mellitus

Tags

Tags

International impact, Reviewed
Změněno: 11/5/2020 11:29, Mgr. Tereza Miškechová

Abstract

V originále

Background: The study was designed to investigate the association between polymorphisms of the. arachidonate 5-lipoxygenase (ALOX5) gene (rs12762303) and the arachidonate 5-lipoxygenase-activating proteingene (rs3802278), and markers of carotid atherosclerosis, such as carotid intima media thickness, the number of affected segments of carotid arteries and the sum of plaque thickness in patients with T2DM. Patients and methods: 595 T2DM subjects and 200 control subjects were enrolled. The carotid intima-media thickness (CIMT) and plaque characteristics (presence and structure) were assessed ultrasonographically. Biochemical analyses were performed using standard biochemical methods. Genotyping of the ALOX5 gene (rs12762303) and the ALOX5AP gene (rs3802278) was performed using KASPar assays. Results: In our study, we demonstrated an association between the rs3802278 and CIMT, and between the rs12762303 and coronary calcium score in subjects with T2DM. In our study, we did not demonstrate any association between tested polymorphisms (rs12762303 and rs3802278) and the sum of plaque thickness, the number of involved segments, hsCRP, the presence of carotid plaques or the presence of unstable carotid plaques. Conclusions: To conclude, in our study we demonstrated an association between the rs3802278 and CIMT, and between the rs12762303 and coronary calcium score in subjects with T2DM.