J 2020

The Influence of Microscopic Inflammation at Resection Margins on Early Postoperative Endoscopic Recurrence After Ileocaecal Resection for Crohn's Disease

POREDSKÁ, Karolina, Lumír KUNOVSKÝ, Filip MAREK, Zdeněk KALA, Vladimír PROCHÁZKA et. al.

Basic information

Original name

The Influence of Microscopic Inflammation at Resection Margins on Early Postoperative Endoscopic Recurrence After Ileocaecal Resection for Crohn's Disease

Authors

POREDSKÁ, Karolina (203 Czech Republic, belonging to the institution), Lumír KUNOVSKÝ (203 Czech Republic, guarantor, belonging to the institution), Filip MAREK (203 Czech Republic, belonging to the institution), Zdeněk KALA (203 Czech Republic, belonging to the institution), Vladimír PROCHÁZKA (203 Czech Republic, belonging to the institution), Jiří DOLINA (203 Czech Republic, belonging to the institution), Vladimír ZBOŘIL (203 Czech Republic, belonging to the institution), Petra KOVALČÍKOVÁ (203 Czech Republic, belonging to the institution), Tomáš PAVLÍK (203 Czech Republic, belonging to the institution), Petr JABANDŽIEV (203 Czech Republic, belonging to the institution), Zdeněk PAVLOVSKÝ (203 Czech Republic, belonging to the institution), Jakub VLAŽNÝ (203 Czech Republic, belonging to the institution) and Ladislav MITÁŠ (203 Czech Republic, belonging to the institution)

Edition

Journal of Crohn's and Colitis, Oxford, OXFORD UNIV PRESS, 2020, 1873-9946

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30219 Gastroenterology and hepatology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 9.071

RIV identification code

RIV/00216224:14110/20:00115594

Organization unit

Faculty of Medicine

DOI

UT WoS

000536439600012

Keywords in English

Crohn's disease; ileocaecal resection; early postoperative endoscopic recurrence

Tags

Tags

International impact, Reviewed
Změněno: 14/7/2020 09:31, Mgr. Tereza Miškechová

Abstract

V originále

Background and Aims: The pathogenesis and risk factors for early postoperative endoscopic recurrence of Crohn's disease [CD] remain unclear. Thus, this study aimed to identify whether histological inflammation at the resection margins after an ileocaecal resection influences endoscopic recurrence. Methods: We have prospectively followed up patients with CD who underwent ileocaecal resection at our hospital between January 2012 and January 2018. The specimens were histologically analysed for inflammation at both of the resection margins [ileal and colonic]. We evaluated whether histological results of the resection margins are correlated with endoscopic recurrence of CD based on colonoscopy 6 months after ileocaecal resection. Second, we assessed the influence of known risk factors and preoperative therapy on endoscopic recurrence of CD. Results: A total of 107 patients were included in our study. Six months after ileocaecal resection, 23 patients [21.5%] had an endoscopic recurrence of CD. The histological signs of CD at the resection margins were associated with a higher endoscopic recurrence [56.5% versus 4.8%, p < 0.001]. Disease duration from diagnosis to surgery [p = 0.006] and the length of the resected bowel [p = 0.019] were significantly longer in patients with endoscopic recurrence. Smoking was also proved to be a risk factor for endoscopic recurrence [p = 0.028]. Conclusions: Histological inflammation at the resection margins was significantly associated with a higher risk of early postoperative endoscopic recurrence after an ileocaecal resection for CD.