| POREDSKÁ, Karolina, Lumír KUNOVSKÝ, Filip MAREK, Zdeněk KALA, Vladimír PROCHÁZKA, Jiří DOLINA, Vladimír ZBOŘIL, Petra KOVALČÍKOVÁ, Tomáš PAVLÍK, Petr JABANDŽIEV, Zdeněk PAVLOVSKÝ, Jakub VLAŽNÝ and Ladislav MITÁŠ. The Influence of Microscopic Inflammation at Resection Margins on Early Postoperative Endoscopic Recurrence After Ileocaecal Resection for Crohn's Disease. Journal of Crohn's and Colitis. Oxford: OXFORD UNIV PRESS, 2020, vol. 14, No 3, p. 361-368. ISSN 1873-9946. Available from: https://dx.doi.org/10.1093/ecco-jcc/jjz153. |
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@article{1652396,
author = {Poredská, Karolina and Kunovský, Lumír and Marek, Filip and Kala, Zdeněk and Procházka, Vladimír and Dolina, Jiří and Zbořil, Vladimír and Kovalčíková, Petra and Pavlík, Tomáš and Jabandžiev, Petr and Pavlovský, Zdeněk and Vlažný, Jakub and Mitáš, Ladislav},
article_location = {Oxford},
article_number = {3},
doi = {http://dx.doi.org/10.1093/ecco-jcc/jjz153},
keywords = {Crohn's disease; ileocaecal resection; early postoperative endoscopic recurrence},
language = {eng},
issn = {1873-9946},
journal = {Journal of Crohn's and Colitis},
title = {The Influence of Microscopic Inflammation at Resection Margins on Early Postoperative Endoscopic Recurrence After Ileocaecal Resection for Crohn's Disease},
url = {https://academic.oup.com/ecco-jcc/article/14/3/361/5566479},
volume = {14},
year = {2020}
}
TY - JOUR
ID - 1652396
AU - Poredská, Karolina - Kunovský, Lumír - Marek, Filip - Kala, Zdeněk - Procházka, Vladimír - Dolina, Jiří - Zbořil, Vladimír - Kovalčíková, Petra - Pavlík, Tomáš - Jabandžiev, Petr - Pavlovský, Zdeněk - Vlažný, Jakub - Mitáš, Ladislav
PY - 2020
TI - The Influence of Microscopic Inflammation at Resection Margins on Early Postoperative Endoscopic Recurrence After Ileocaecal Resection for Crohn's Disease
JF - Journal of Crohn's and Colitis
VL - 14
IS - 3
SP - 361-368
EP - 361-368
PB - OXFORD UNIV PRESS
SN - 18739946
KW - Crohn's disease
KW - ileocaecal resection
KW - early postoperative endoscopic recurrence
UR - https://academic.oup.com/ecco-jcc/article/14/3/361/5566479
L2 - https://academic.oup.com/ecco-jcc/article/14/3/361/5566479
N2 - Background and Aims: The pathogenesis and risk factors for early postoperative endoscopic recurrence of Crohn's disease [CD] remain unclear. Thus, this study aimed to identify whether histological inflammation at the resection margins after an ileocaecal resection influences endoscopic recurrence. Methods: We have prospectively followed up patients with CD who underwent ileocaecal resection at our hospital between January 2012 and January 2018. The specimens were histologically analysed for inflammation at both of the resection margins [ileal and colonic]. We evaluated whether histological results of the resection margins are correlated with endoscopic recurrence of CD based on colonoscopy 6 months after ileocaecal resection. Second, we assessed the influence of known risk factors and preoperative therapy on endoscopic recurrence of CD. Results: A total of 107 patients were included in our study. Six months after ileocaecal resection, 23 patients [21.5%] had an endoscopic recurrence of CD. The histological signs of CD at the resection margins were associated with a higher endoscopic recurrence [56.5% versus 4.8%, p < 0.001]. Disease duration from diagnosis to surgery [p = 0.006] and the length of the resected bowel [p = 0.019] were significantly longer in patients with endoscopic recurrence. Smoking was also proved to be a risk factor for endoscopic recurrence [p = 0.028]. Conclusions: Histological inflammation at the resection margins was significantly associated with a higher risk of early postoperative endoscopic recurrence after an ileocaecal resection for CD.
ER -
POREDSKÁ, Karolina, Lumír KUNOVSKÝ, Filip MAREK, Zdeněk KALA, Vladimír PROCHÁZKA, Jiří DOLINA, Vladimír ZBOŘIL, Petra KOVALČÍKOVÁ, Tomáš PAVLÍK, Petr JABANDŽIEV, Zdeněk PAVLOVSKÝ, Jakub VLAŽNÝ and Ladislav MITÁŠ. The Influence of Microscopic Inflammation at Resection Margins on Early Postoperative Endoscopic Recurrence After Ileocaecal Resection for Crohn's Disease. \textit{Journal of Crohn's and Colitis}. Oxford: OXFORD UNIV PRESS, 2020, vol.~14, No~3, p.~361-368. ISSN~1873-9946. Available from: https://dx.doi.org/10.1093/ecco-jcc/jjz153.
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