NĚMEČKOVÁ, Dana, Eva HAVRÁNKOVÁ, Jan ŠIMBERA, Richard ŠEVČÍK a Pavel PAZDERA. Simplified Procedure for General Synthesis of Monosubstituted Piperazines—From a Batch Reaction Vessel to a Flow (Microwave) Reactor. Molecules. Basel: MDPI, 2020, roč. 25, č. 9, s. 1-15. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules25092168. |
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@article{1652656, author = {Němečková, Dana and Havránková, Eva and Šimbera, Jan and Ševčík, Richard and Pazdera, Pavel}, article_location = {Basel}, article_number = {9}, doi = {http://dx.doi.org/10.3390/molecules25092168}, keywords = {piperazine; monosubstituted; derivative; heterocyclic; catalysis; heterogeneous; microwave; synthesis; supported catalyst; reactor}, language = {eng}, issn = {1420-3049}, journal = {Molecules}, title = {Simplified Procedure for General Synthesis of Monosubstituted Piperazines—From a Batch Reaction Vessel to a Flow (Microwave) Reactor}, url = {https://doi.org/10.3390/molecules25092168}, volume = {25}, year = {2020} }
TY - JOUR ID - 1652656 AU - Němečková, Dana - Havránková, Eva - Šimbera, Jan - Ševčík, Richard - Pazdera, Pavel PY - 2020 TI - Simplified Procedure for General Synthesis of Monosubstituted Piperazines—From a Batch Reaction Vessel to a Flow (Microwave) Reactor JF - Molecules VL - 25 IS - 9 SP - 1-15 EP - 1-15 PB - MDPI SN - 14203049 KW - piperazine KW - monosubstituted KW - derivative KW - heterocyclic KW - catalysis KW - heterogeneous KW - microwave KW - synthesis KW - supported catalyst KW - reactor UR - https://doi.org/10.3390/molecules25092168 L2 - https://doi.org/10.3390/molecules25092168 N2 - We reported a novel simplified synthetic procedure for the preparation of monosubstituted piperazine derivatives which can now be easily prepared in a one-pot-one-step way from a protonated piperazine with no need of introduction of a protecting group. Reactions, proceeding either at room or higher temperatures in common solvents, involve heterogeneous catalysis by metal ions supported on commercial polymeric resins. A general synthetic scheme was successfully applied to afford a wide range of monosubstituted piperazines. Furthermore, we picked up a set of piperazine derivatives and studied the possibilities of microwave acceleration of given synthetic reactions to make them even more efficient. Our research proceeded from a simple batch technique to the construction of a flow microwave reactor prototype and resulted in promising findings which are summarized and discussed in the article. ER -
NĚMEČKOVÁ, Dana, Eva HAVRÁNKOVÁ, Jan ŠIMBERA, Richard ŠEVČÍK a Pavel PAZDERA. Simplified Procedure for General Synthesis of Monosubstituted Piperazines—From a Batch Reaction Vessel to a Flow (Microwave) Reactor. \textit{Molecules}. Basel: MDPI, 2020, roč.~25, č.~9, s.~1-15. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules25092168.
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