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@article{1653758,
author = {Slezáková, Simona and Bořilová Linhartová, Petra and Bartova, Jirina and Petanova, Jitka and Kuklínek, Pavel and Fassmann, Antonín and Izakovičová Hollá, Lydie},
article_location = {Oxford},
article_number = {FEB 2020},
doi = {http://dx.doi.org/10.1016/j.archoralbio.2019.104628},
keywords = {Serotonin transporter gene; SLC6A4; Recurrent aphthous stomatitis; Polymorphism},
language = {eng},
issn = {0003-9969},
journal = {Archives of Oral Biology},
title = {Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis},
url = {https://www.sciencedirect.com/science/article/pii/S0003996919309975?via%3Dihub},
volume = {110},
year = {2020}
}
TY - JOUR
ID - 1653758
AU - Slezáková, Simona - Bořilová Linhartová, Petra - Bartova, Jirina - Petanova, Jitka - Kuklínek, Pavel - Fassmann, Antonín - Izakovičová Hollá, Lydie
PY - 2020
TI - Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis
JF - Archives of Oral Biology
VL - 110
IS - FEB 2020
SP - 1-6
EP - 1-6
PB - Pergamon-Elsevier
SN - 00039969
KW - Serotonin transporter gene
KW - SLC6A4
KW - Recurrent aphthous stomatitis
KW - Polymorphism
UR - https://www.sciencedirect.com/science/article/pii/S0003996919309975?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S0003996919309975?via%3Dihub
N2 - Objective: The aim of this study was to investigate five polymorphisms in the SLC6A4 gene in patients with recurrent aphthous stomatitis (RAS) and healthy controls. Design: Totally, 239 subjects were enrolled in this case-control study: 86 patients with RAS and 153 healthy individuals were genotyped for serotonin transporter length polymorphic region (5-HTTLPR) polymorphism, variable number tandem repeat (STin2) and single nucleotide polymorphisms (rs25531, rs3813034, rs1042173) in the SLC6A4 gene by polymerase chain reaction with/without restriction analysis. Results: No significant differences in the allele or genotype frequencies in all studied polymorphisms between RAS patients and healthy controls (P > 0.05) were detected. However, the haplotype analysis detected a higher frequency of LA12 (HTTLPR, rs25531, STin2) haplotype in RAS patients in comparison with healthy controls (P < 0.05, OR = 1.63, 95 % CI = 1.07-2.49). Conclusions: Our study indicates a possible relationship between SLC6A4 and susceptibility to RAS in the Czech population.
ER -
SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLÍNEK, Antonín FASSMANN a Lydie IZAKOVIČOVÁ HOLLÁ. Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis. Online. \textit{Archives of Oral Biology}. Oxford: Pergamon-Elsevier, 2020, roč.~110, FEB 2020, s.~1-6. ISSN~0003-9969. Dostupné z: https://dx.doi.org/10.1016/j.archoralbio.2019.104628. [citováno 2024-04-23]
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