Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLÍNEK, Antonín FASSMANN and Lydie IZAKOVIČOVÁ HOLLÁ. Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis. Archives of Oral Biology. Oxford: Pergamon-Elsevier, 2020, vol. 110, FEB 2020, p. 1-6. ISSN 0003-9969. Available from: https://dx.doi.org/10.1016/j.archoralbio.2019.104628.

Basic information

• Original name: Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis
• Authors: SLEZÁKOVÁ, Simona (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Jirina BARTOVA (203 Czech Republic), Jitka PETANOVA (203 Czech Republic), Pavel KUKLÍNEK (203 Czech Republic, belonging to the institution), Antonín FASSMANN (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Archives of Oral Biology, Oxford, Pergamon-Elsevier, 2020, 0003-9969.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30208 Dentistry, oral surgery and medicine
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.633
• RIV identification code: RIV/00216224:14110/20:00115613
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.archoralbio.2019.104628
• UT WoS: 000523654000026
• Keywords in English: Serotonin transporter gene; SLC6A4; Recurrent aphthous stomatitis; Polymorphism
• Tags: 14110114, 14110130, 14110518, rivok
• Tags: International impact, Reviewed

Abstract

Objective: The aim of this study was to investigate five polymorphisms in the SLC6A4 gene in patients with recurrent aphthous stomatitis (RAS) and healthy controls. Design: Totally, 239 subjects were enrolled in this case-control study: 86 patients with RAS and 153 healthy individuals were genotyped for serotonin transporter length polymorphic region (5-HTTLPR) polymorphism, variable number tandem repeat (STin2) and single nucleotide polymorphisms (rs25531, rs3813034, rs1042173) in the SLC6A4 gene by polymerase chain reaction with/without restriction analysis. Results: No significant differences in the allele or genotype frequencies in all studied polymorphisms between RAS patients and healthy controls (P > 0.05) were detected. However, the haplotype analysis detected a higher frequency of LA12 (HTTLPR, rs25531, STin2) haplotype in RAS patients in comparison with healthy controls (P < 0.05, OR = 1.63, 95 % CI = 1.07-2.49). Conclusions: Our study indicates a possible relationship between SLC6A4 and susceptibility to RAS in the Czech population.

Links

• MUNI/A/1546/2018, interní kód MU: Name: Etiopatogeneze, diagnostika a léčba vybraných onemocnění dutiny ústní a jejich souvislost s celkovým zdravotním stavem

Investor: Masaryk University, Category A

• ROZV/23/LF1/2019, interní kód MU: Name: Studium genetické predispozice hostitele a jeho mikrobiomu ve vztahu k chorobám dutiny ústní na jícnu

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects