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@article{1653758, author = {Slezáková, Simona and Bořilová Linhartová, Petra and Bartova, Jirina and Petanova, Jitka and Kuklínek, Pavel and Fassmann, Antonín and Izakovičová Hollá, Lydie}, article_location = {Oxford}, article_number = {FEB 2020}, doi = {http://dx.doi.org/10.1016/j.archoralbio.2019.104628}, keywords = {Serotonin transporter gene; SLC6A4; Recurrent aphthous stomatitis; Polymorphism}, language = {eng}, issn = {0003-9969}, journal = {Archives of Oral Biology}, title = {Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis}, url = {https://www.sciencedirect.com/science/article/pii/S0003996919309975?via%3Dihub}, volume = {110}, year = {2020} }
TY - JOUR ID - 1653758 AU - Slezáková, Simona - Bořilová Linhartová, Petra - Bartova, Jirina - Petanova, Jitka - Kuklínek, Pavel - Fassmann, Antonín - Izakovičová Hollá, Lydie PY - 2020 TI - Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis JF - Archives of Oral Biology VL - 110 IS - FEB 2020 SP - 1-6 EP - 1-6 PB - Pergamon-Elsevier SN - 00039969 KW - Serotonin transporter gene KW - SLC6A4 KW - Recurrent aphthous stomatitis KW - Polymorphism UR - https://www.sciencedirect.com/science/article/pii/S0003996919309975?via%3Dihub L2 - https://www.sciencedirect.com/science/article/pii/S0003996919309975?via%3Dihub N2 - Objective: The aim of this study was to investigate five polymorphisms in the SLC6A4 gene in patients with recurrent aphthous stomatitis (RAS) and healthy controls. Design: Totally, 239 subjects were enrolled in this case-control study: 86 patients with RAS and 153 healthy individuals were genotyped for serotonin transporter length polymorphic region (5-HTTLPR) polymorphism, variable number tandem repeat (STin2) and single nucleotide polymorphisms (rs25531, rs3813034, rs1042173) in the SLC6A4 gene by polymerase chain reaction with/without restriction analysis. Results: No significant differences in the allele or genotype frequencies in all studied polymorphisms between RAS patients and healthy controls (P > 0.05) were detected. However, the haplotype analysis detected a higher frequency of LA12 (HTTLPR, rs25531, STin2) haplotype in RAS patients in comparison with healthy controls (P < 0.05, OR = 1.63, 95 % CI = 1.07-2.49). Conclusions: Our study indicates a possible relationship between SLC6A4 and susceptibility to RAS in the Czech population. ER -
SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLÍNEK, Antonín FASSMANN and Lydie IZAKOVIČOVÁ HOLLÁ. Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis. \textit{Archives of Oral Biology}. Oxford: Pergamon-Elsevier, 2020, vol.~110, FEB 2020, p.~1-6. ISSN~0003-9969. Available from: https://dx.doi.org/10.1016/j.archoralbio.2019.104628.
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