Serotonin transporter gene (SLC6A4) variability in patients
with recurrent aphthous stomatitis

J 2020

Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLÍNEK et. al.

Basic information

Original name

Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis

Authors

SLEZÁKOVÁ, Simona (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Jirina BARTOVA (203 Czech Republic), Jitka PETANOVA (203 Czech Republic), Pavel KUKLÍNEK (203 Czech Republic, belonging to the institution), Antonín FASSMANN (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Archives of Oral Biology, Oxford, Pergamon-Elsevier, 2020, 0003-9969

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30208 Dentistry, oral surgery and medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.633

RIV identification code

RIV/00216224:14110/20:00115613

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.archoralbio.2019.104628

UT WoS

000523654000026

Keywords in English

Serotonin transporter gene; SLC6A4; Recurrent aphthous stomatitis; Polymorphism

Abstract

V originále

Objective: The aim of this study was to investigate five polymorphisms in the SLC6A4 gene in patients with recurrent aphthous stomatitis (RAS) and healthy controls. Design: Totally, 239 subjects were enrolled in this case-control study: 86 patients with RAS and 153 healthy individuals were genotyped for serotonin transporter length polymorphic region (5-HTTLPR) polymorphism, variable number tandem repeat (STin2) and single nucleotide polymorphisms (rs25531, rs3813034, rs1042173) in the SLC6A4 gene by polymerase chain reaction with/without restriction analysis. Results: No significant differences in the allele or genotype frequencies in all studied polymorphisms between RAS patients and healthy controls (P > 0.05) were detected. However, the haplotype analysis detected a higher frequency of LA12 (HTTLPR, rs25531, STin2) haplotype in RAS patients in comparison with healthy controls (P < 0.05, OR = 1.63, 95 % CI = 1.07-2.49). Conclusions: Our study indicates a possible relationship between SLC6A4 and susceptibility to RAS in the Czech population.

Links

MUNI/A/1546/2018, interní kód MU

Name: Etiopatogeneze, diagnostika a léčba vybraných onemocnění dutiny ústní a jejich souvislost s celkovým zdravotním stavem

Investor: Masaryk University, Category A

ROZV/23/LF1/2019, interní kód MU

Name: Studium genetické predispozice hostitele a jeho mikrobiomu ve vztahu k chorobám dutiny ústní na jícnu

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLÍNEK, Antonín FASSMANN and Lydie IZAKOVIČOVÁ HOLLÁ. Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis. Archives of Oral Biology. Oxford: Pergamon-Elsevier, 2020, vol. 110, FEB 2020, p. 1-6. ISSN 0003-9969. Available from: https://dx.doi.org/10.1016/j.archoralbio.2019.104628.

@article{1653758,
   author = {Slezáková, Simona and Bořilová Linhartová, Petra and Bartova, Jirina and Petanova, Jitka and Kuklínek, Pavel and Fassmann, Antonín and Izakovičová Hollá, Lydie},
   article_location = {Oxford},
   article_number = {FEB 2020},
   doi = {http://dx.doi.org/10.1016/j.archoralbio.2019.104628},
   keywords = {Serotonin transporter gene; SLC6A4; Recurrent aphthous stomatitis; Polymorphism},
   language = {eng},
   issn = {0003-9969},
   journal = {Archives of Oral Biology},
   title = {Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis},
   url = {https://www.sciencedirect.com/science/article/pii/S0003996919309975?via%3Dihub},
   volume = {110},
   year = {2020}
}

TY  - JOUR
ID  - 1653758
AU  - Slezáková, Simona - Bořilová Linhartová, Petra - Bartova, Jirina - Petanova, Jitka - Kuklínek, Pavel - Fassmann, Antonín - Izakovičová Hollá, Lydie
PY  - 2020
TI  - Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis
JF  - Archives of Oral Biology
VL  - 110
IS  - FEB 2020
SP  - 1-6
EP  - 1-6
PB  - Pergamon-Elsevier
SN  - 00039969
KW  - Serotonin transporter gene
KW  - SLC6A4
KW  - Recurrent aphthous stomatitis
KW  - Polymorphism
UR  - https://www.sciencedirect.com/science/article/pii/S0003996919309975?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0003996919309975?via%3Dihub
N2  - Objective: The aim of this study was to investigate five polymorphisms in the SLC6A4 gene in patients with recurrent aphthous stomatitis (RAS) and healthy controls. Design: Totally, 239 subjects were enrolled in this case-control study: 86 patients with RAS and 153 healthy individuals were genotyped for serotonin transporter length polymorphic region (5-HTTLPR) polymorphism, variable number tandem repeat (STin2) and single nucleotide polymorphisms (rs25531, rs3813034, rs1042173) in the SLC6A4 gene by polymerase chain reaction with/without restriction analysis. Results: No significant differences in the allele or genotype frequencies in all studied polymorphisms between RAS patients and healthy controls (P > 0.05) were detected. However, the haplotype analysis detected a higher frequency of LA12 (HTTLPR, rs25531, STin2) haplotype in RAS patients in comparison with healthy controls (P < 0.05, OR = 1.63, 95 % CI = 1.07-2.49). Conclusions: Our study indicates a possible relationship between SLC6A4 and susceptibility to RAS in the Czech population.
ER  -

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLÍNEK, Antonín FASSMANN and Lydie IZAKOVIČOVÁ HOLLÁ. Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis. \textit{Archives of Oral Biology}. Oxford: Pergamon-Elsevier, 2020, vol.~110, FEB 2020, p.~1-6. ISSN~0003-9969. Available from: https://dx.doi.org/10.1016/j.archoralbio.2019.104628.

Detailed Information on Publication Record