| PEJŠKOVÁ, Petra, Madeline Louise REILLY, Lucia BINÓ, Ondřej BERNATÍK, Linda DOLANSKÁ, Sri Ranjani GANJI, Zbyněk ZDRÁHAL, Alexandre BENMERAH and Lukáš ČAJÁNEK. KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling. JOURNAL OF CELL BIOLOGY. New York: ROCKEFELLER UNIVERSITY PRESS, 2020, vol. 219, No 6, p. "1-23"-"S1-S6", 29 pp. ISSN 0021-9525. Available from: https://dx.doi.org/10.1083/jcb.201904107. |
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@article{1654416,
author = {Pejšková, Petra and Reilly, Madeline Louise and Binó, Lucia and Bernatík, Ondřej and Dolanská, Linda and Ganji, Sri Ranjani and Zdráhal, Zbyněk and Benmerah, Alexandre and Čajánek, Lukáš},
article_location = {New York},
article_number = {6},
doi = {http://dx.doi.org/10.1083/jcb.201904107},
keywords = {PRIMARY CILIUM; MOTHER CENTRIOLE; MOTOR PROTEINS; SONIC HEDGEHOG; EARLY STEPS; KINESIN-II; CELL-CYCLE; A KINASE; ACTIVATION; CEP164},
language = {eng},
issn = {0021-9525},
journal = {JOURNAL OF CELL BIOLOGY},
title = {KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling},
url = {https://rupress.org/jcb/article/219/6/e201904107/151721/KIF14-controls-ciliogenesis-via-regulation-of?searchresult=1},
volume = {219},
year = {2020}
}
TY - JOUR
ID - 1654416
AU - Pejšková, Petra - Reilly, Madeline Louise - Binó, Lucia - Bernatík, Ondřej - Dolanská, Linda - Ganji, Sri Ranjani - Zdráhal, Zbyněk - Benmerah, Alexandre - Čajánek, Lukáš
PY - 2020
TI - KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling
JF - JOURNAL OF CELL BIOLOGY
VL - 219
IS - 6
SP - "1-23"-"S1-S6"
EP - "1-23"-"S1-S6"
PB - ROCKEFELLER UNIVERSITY PRESS
SN - 00219525
KW - PRIMARY CILIUM
KW - MOTHER CENTRIOLE
KW - MOTOR PROTEINS
KW - SONIC HEDGEHOG
KW - EARLY STEPS
KW - KINESIN-II
KW - CELL-CYCLE
KW - A KINASE
KW - ACTIVATION
KW - CEP164
UR - https://rupress.org/jcb/article/219/6/e201904107/151721/KIF14-controls-ciliogenesis-via-regulation-of?searchresult=1
L2 - https://rupress.org/jcb/article/219/6/e201904107/151721/KIF14-controls-ciliogenesis-via-regulation-of?searchresult=1
N2 - Primary cilia play critical roles in development and disease. Their assembly and disassembly are tightly coupled to cell cycle progression. Here, we present data identifying KIF14 as a regulator of cilia formation and Hedgehog (HH) signaling. We show that RNAi depletion of KIF14 specifically leads to defects in ciliogenesis and basal body (BB) biogenesis, as its absence hampers the efficiency of primary cilium formation and the dynamics of primary cilium elongation, and disrupts the localization of the distal appendage proteins SCLT1 and FBF1 and components of the IFT-B complex. We identify deregulated Aurora A activity as a mechanism contributing to the primary cilium and BB formation defects seen after KIF14 depletion. In addition, we show that primary cilia in KIF14-depleted cells are defective in response to HH pathway activation, independently of the effects of Aurora A. In sum, our data point to KIF14 as a critical node connecting cell cycle machinery, effective ciliogenesis, and HH signaling.
ER -
PEJŠKOVÁ, Petra, Madeline Louise REILLY, Lucia BINÓ, Ondřej BERNATÍK, Linda DOLANSKÁ, Sri Ranjani GANJI, Zbyněk ZDRÁHAL, Alexandre BENMERAH and Lukáš ČAJÁNEK. KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling. \textit{JOURNAL OF CELL BIOLOGY}. New York: ROCKEFELLER UNIVERSITY PRESS, 2020, vol.~219, No~6, p.~''1-23''-''S1-S6'', 29 pp. ISSN~0021-9525. Available from: https://dx.doi.org/10.1083/jcb.201904107.
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