J 2020

Altered directed functional connectivity of the right amygdala in depression: high-density EEG study

DAMBORSKÁ, Alena, Eliška HONZÍRKOVÁ, Elis BARTEČKŮ, Jana HOŘÍNKOVÁ, Sylvie FEDOROVÁ et. al.

Basic information

Original name

Altered directed functional connectivity of the right amygdala in depression: high-density EEG study

Authors

DAMBORSKÁ, Alena (203 Czech Republic, guarantor, belonging to the institution), Eliška HONZÍRKOVÁ (203 Czech Republic, belonging to the institution), Elis BARTEČKŮ (203 Czech Republic, belonging to the institution), Jana HOŘÍNKOVÁ (203 Czech Republic, belonging to the institution), Sylvie FEDOROVÁ (203 Czech Republic, belonging to the institution), Šimon ONDRUŠ (203 Czech Republic, belonging to the institution), Christoph M. MICHEL (756 Switzerland) and Maria RUBEGA (756 Switzerland)

Edition

Scientific Reports, London, Nature Publishing Group, 2020, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30215 Psychiatry

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.379

RIV identification code

RIV/00216224:14110/20:00115781

Organization unit

Faculty of Medicine

DOI

UT WoS

000537496200001

Keywords in English

Depression; Electroencephalography- EEG; Neural Circuits; Psychiatric Disorders

Tags

Tags

International impact, Reviewed
Změněno: 3/8/2020 07:20, Mgr. Tereza Miškechová

Abstract

V originále

The cortico-striatal-pallidal-thalamic and limbic circuits are suggested to play a crucial role in the pathophysiology of depression. Stimulation of deep brain targets might improve symptoms in treatment-resistant depression. However, a better understanding of connectivity properties of deep brain structures potentially implicated in deep brain stimulation (DBS) treatment is needed. Using high-density EEG, we explored the directed functional connectivity at rest in 25 healthy subjects and 26 patients with moderate to severe depression within the bipolar affective disorder, depressive episode, and recurrent depressive disorder. We computed the Partial Directed Coherence on the source EEG signals focusing on the amygdala, anterior cingulate, putamen, pallidum, caudate, and thalamus. The global efficiency for the whole brain and the local efficiency, clustering coefficient, outflow, and strength for the selected structures were calculated. In the right amygdala, all the network metrics were significantly higher (p < 0.001) in patients than in controls. The global efficiency was significantly higher (p < 0.05) in patients than in controls, showed no correlation with status of depression, but decreased with increasing medication intake (R-2 = 0.59 and p = 1.52e-05). The amygdala seems to play an important role in neurobiology of depression. Practical treatment studies would be necessary to assess the amygdala as a potential future DBS target for treating depression.