Activation of the Nitric Oxide Pathway and Acute Myocardial
Infarction Complicated by Acute Kidney Injury

J 2020

Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury

PAŘENICA, Jiří, Petr KALA, Alexandre MEBAZAA, Simona LITTNEROVÁ, Klára BENEŠOVÁ et. al.

Basic information

Original name

Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury

Authors

PAŘENICA, Jiří (203 Czech Republic, belonging to the institution), Petr KALA (203 Czech Republic, belonging to the institution), Alexandre MEBAZAA (250 France), Simona LITTNEROVÁ (203 Czech Republic, belonging to the institution), Klára BENEŠOVÁ (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Marie TOMANDLOVÁ (203 Czech Republic, belonging to the institution), Milan DASTYCH (203 Czech Republic, belonging to the institution), Can INCE (528 Netherlands), Kateřina HELÁNOVÁ (203 Czech Republic, belonging to the institution), Martin TESÁK (203 Czech Republic, belonging to the institution), Martin HELÁN (203 Czech Republic, belonging to the institution), Petr LOKAJ (203 Czech Republic, belonging to the institution) and Matthieu LEGRAND (250 France, guarantor)

Edition

CARDIORENAL MEDICINE, BASEL, KARGER, 2020, 1664-3828

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.041

RIV identification code

RIV/00216224:14110/20:00115794

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1159/000503718

UT WoS

000526816300002

Keywords in English

Acute kidney injury; Nitric oxide; Myocardial infarction; Oxidative stress; Cardio renal

Abstract

V originále

Background/Aims: The pathophysiology of acute kidney injury (AKI) in ST-elevation myocardial infarction (STEMI) patients remains poorly explored. The involvement of the nitric oxide (NO) pathway has been demonstrated in experimental ischemic AKI. The aim of this study was to assess the predictive value of circulating biomarkers of the NO pathway for AKI in STEMI patients. Methods: Four hundred and twenty-seven STEMI patients treated with primary percutaneous coronary intervention were included. The primary end point was AKI. Biomarkers of the NO pathway (plasma superoxide dismutase [SOD], uric acid, nitrite/nitrate [NOx], neopterin) as well as cardiac biomarkers (B-type natriuretic peptide [BNP] and troponin) were sampled 12 h after admission. The predictive value of circulating biomarkers was evaluated in addition to the multivariate clinical model. Results: AKI developed in 8.9% of patients. The 3-month mortality was significantly higher in patients with AKI (34.2 vs. 4.1%; p < 0.001). SOD, uric acid, NOx, neopterin, BNP and troponin were significantly associated with the development of AKI (area under curve [AUC]-receiver operating curve [ROC] ranging between 0.70 and 0.81). In multivariate analysis cardiogenic shock, neopterin, NOx and troponin were independent predictors of AKI. AUC-ROC of the association of multibiomarkers and clinical model was 0.90 and outperformed the predictive value of the clinical model alone. OR of NOx >= 45 mu mol/L was 8.0 (95% CI 3.1-20.6) for AKI. Conclusion: Biomarkers of the NO pathway are associated with the development of AKI in STEMI patients. These results provide insights into the pathophysiology of AKI and may serve at developing preventing strategies for AKI targeting this pathway.

Links

MUNI/A/1250/2017, interní kód MU

Name: Validace Rule-out/rule-in protokolu u pacientů s bolestí na hrudi – pokračování v prospektivní studii

Investor: Masaryk University, Category A

Citovat

PAŘENICA, Jiří, Petr KALA, Alexandre MEBAZAA, Simona LITTNEROVÁ, Klára BENEŠOVÁ, Josef TOMANDL, Monika PÁVKOVÁ GOLDBERGOVÁ, Jiří JARKOVSKÝ, Jindřich ŠPINAR, Marie TOMANDLOVÁ, Milan DASTYCH, Can INCE, Kateřina HELÁNOVÁ, Martin TESÁK, Martin HELÁN, Petr LOKAJ and Matthieu LEGRAND. Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury. CARDIORENAL MEDICINE. BASEL: KARGER, 2020, vol. 10, No 2, p. 85-96. ISSN 1664-3828. Available from: https://dx.doi.org/10.1159/000503718.

@article{1662576,
   author = {Pařenica, Jiří and Kala, Petr and Mebazaa, Alexandre and Littnerová, Simona and Benešová, Klára and Tomandl, Josef and Pávková Goldbergová, Monika and Jarkovský, Jiří and Špinar, Jindřich and Tomandlová, Marie and Dastych, Milan and Ince, Can and Helánová, Kateřina and Tesák, Martin and Helán, Martin and Lokaj, Petr and Legrand, Matthieu},
   article_location = {BASEL},
   article_number = {2},
   doi = {http://dx.doi.org/10.1159/000503718},
   keywords = {Acute kidney injury; Nitric oxide; Myocardial infarction; Oxidative stress; Cardio renal},
   language = {eng},
   issn = {1664-3828},
   journal = {CARDIORENAL MEDICINE},
   title = {Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury},
   url = {https://www.karger.com/Article/FullText/503718},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1662576
AU  - Pařenica, Jiří - Kala, Petr - Mebazaa, Alexandre - Littnerová, Simona - Benešová, Klára - Tomandl, Josef - Pávková Goldbergová, Monika - Jarkovský, Jiří - Špinar, Jindřich - Tomandlová, Marie - Dastych, Milan - Ince, Can - Helánová, Kateřina - Tesák, Martin - Helán, Martin - Lokaj, Petr - Legrand, Matthieu
PY  - 2020
TI  - Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury
JF  - CARDIORENAL MEDICINE
VL  - 10
IS  - 2
SP  - 85-96
EP  - 85-96
PB  - KARGER
SN  - 16643828
KW  - Acute kidney injury
KW  - Nitric oxide
KW  - Myocardial infarction
KW  - Oxidative stress
KW  - Cardio renal
UR  - https://www.karger.com/Article/FullText/503718
L2  - https://www.karger.com/Article/FullText/503718
N2  - Background/Aims: The pathophysiology of acute kidney injury (AKI) in ST-elevation myocardial infarction (STEMI) patients remains poorly explored. The involvement of the nitric oxide (NO) pathway has been demonstrated in experimental ischemic AKI. The aim of this study was to assess the predictive value of circulating biomarkers of the NO pathway for AKI in STEMI patients. Methods: Four hundred and twenty-seven STEMI patients treated with primary percutaneous coronary intervention were included. The primary end point was AKI. Biomarkers of the NO pathway (plasma superoxide dismutase [SOD], uric acid, nitrite/nitrate [NOx], neopterin) as well as cardiac biomarkers (B-type natriuretic peptide [BNP] and troponin) were sampled 12 h after admission. The predictive value of circulating biomarkers was evaluated in addition to the multivariate clinical model. Results: AKI developed in 8.9% of patients. The 3-month mortality was significantly higher in patients with AKI (34.2 vs. 4.1%; p < 0.001). SOD, uric acid, NOx, neopterin, BNP and troponin were significantly associated with the development of AKI (area under curve [AUC]-receiver operating curve [ROC] ranging between 0.70 and 0.81). In multivariate analysis cardiogenic shock, neopterin, NOx and troponin were independent predictors of AKI. AUC-ROC of the association of multibiomarkers and clinical model was 0.90 and outperformed the predictive value of the clinical model alone. OR of NOx >= 45 mu mol/L was 8.0 (95% CI 3.1-20.6) for AKI. Conclusion: Biomarkers of the NO pathway are associated with the development of AKI in STEMI patients. These results provide insights into the pathophysiology of AKI and may serve at developing preventing strategies for AKI targeting this pathway.
ER  -

PAŘENICA, Jiří, Petr KALA, Alexandre MEBAZAA, Simona LITTNEROVÁ, Klára BENEŠOVÁ, Josef TOMANDL, Monika PÁVKOVÁ GOLDBERGOVÁ, Jiří JARKOVSKÝ, Jindřich ŠPINAR, Marie TOMANDLOVÁ, Milan DASTYCH, Can INCE, Kateřina HELÁNOVÁ, Martin TESÁK, Martin HELÁN, Petr LOKAJ and Matthieu LEGRAND. Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury. \textit{CARDIORENAL MEDICINE}. BASEL: KARGER, 2020, vol.~10, No~2, p.~85-96. ISSN~1664-3828. Available from: https://dx.doi.org/10.1159/000503718.

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