Effect of Ni ion release on the cells in contact with NiTi
alloys

J 2020

Effect of Ni ion release on the cells in contact with NiTi alloys

VEVERKOVÁ, Jana, Denisa BARTKOVA, Adam WEISER, Antonin DLOUHY, Petr BABULA et. al.

Basic information

Original name

Effect of Ni ion release on the cells in contact with NiTi alloys

Authors

VEVERKOVÁ, Jana (203 Czech Republic, belonging to the institution), Denisa BARTKOVA (203 Czech Republic), Adam WEISER (203 Czech Republic), Antonin DLOUHY (203 Czech Republic), Petr BABULA (203 Czech Republic, belonging to the institution), Petr ŠTĚPKA (203 Czech Republic, belonging to the institution) and Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Environmental Science and Pollution Research, Heidelberg, Springer Heidelberg, 2020, 0944-1344

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10511 Environmental sciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.223

RIV identification code

RIV/00216224:14110/20:00114179

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s11356-019-07506-8

UT WoS

000517084600014

Keywords in English

Nitinol; Cell; Biocompatibility; Biomaterial; Hydrogen modification

Abstract

V originále

Nickel-titanium alloys have been used in medical applications for several years; however, biocompatibility of the material remains controversial. In the present study, the human umbilical vein endothelial cells (HUVEC) were cultured in contact with the nitinol used in two different heat treatment surface modifications-helium and hydrogen. The amount of Ni ions released from these alloys in contact with HUVEC was measured in media and in the cells by ICP-MS. An increased release of Ni ions was detected in He alloy compared with H-2 alloy modification with an elevation with the metal exposition duration (24 h vs. 72 h). The cells contained the Ni ions in both selected alloy modifications with the lower levels in H-2 alloys. To evaluate the potential of multiple metal applications, similar values were observed in media and in cell suspension for all surface modification combinations. The model analysis of effect of metal ion release on distant cells in the body showed that the concentration is interestingly similar to concentrations in cells in direct contact with the metal alloy. The cells are able to regulate the concentration of Ni ions within the cell. According to our best knowledge, the study for the first time describes the presence of Ni ions released from nitinol directly in the cells. In the case of the H-2 modification, the lowest levels of Ni ions were detected both in medium and in the cells, which likely increases the biocompatibility of the nitinol alloy.

Links

GA15-16336S, research and development project

Name: Intersticiální příměsi v tvarově-paměťových slitinách na bázi NiTi

Investor: Czech Science Foundation

MUNI/A/1453/2019, interní kód MU

Name: Příspěvek ke studiu molekulární, buněčné, tkáňové a systémové patofyziologie vybraných komplexních nemocí

Investor: Masaryk University, Category A

Citovat

VEVERKOVÁ, Jana, Denisa BARTKOVA, Adam WEISER, Antonin DLOUHY, Petr BABULA, Petr ŠTĚPKA and Monika PÁVKOVÁ GOLDBERGOVÁ. Effect of Ni ion release on the cells in contact with NiTi alloys. Environmental Science and Pollution Research. Heidelberg: Springer Heidelberg, 2020, vol. 27, No 8, p. 7934-7942. ISSN 0944-1344. Available from: https://dx.doi.org/10.1007/s11356-019-07506-8.

@article{1662578,
   author = {Veverková, Jana and Bartkova, Denisa and Weiser, Adam and Dlouhy, Antonin and Babula, Petr and Štěpka, Petr and Pávková Goldbergová, Monika},
   article_location = {Heidelberg},
   article_number = {8},
   doi = {http://dx.doi.org/10.1007/s11356-019-07506-8},
   keywords = {Nitinol; Cell; Biocompatibility; Biomaterial; Hydrogen modification},
   language = {eng},
   issn = {0944-1344},
   journal = {Environmental Science and Pollution Research},
   title = {Effect of Ni ion release on the cells in contact with NiTi alloys},
   url = {https://link.springer.com/article/10.1007/s11356-019-07506-8},
   volume = {27},
   year = {2020}
}

TY  - JOUR
ID  - 1662578
AU  - Veverková, Jana - Bartkova, Denisa - Weiser, Adam - Dlouhy, Antonin - Babula, Petr - Štěpka, Petr - Pávková Goldbergová, Monika
PY  - 2020
TI  - Effect of Ni ion release on the cells in contact with NiTi alloys
JF  - Environmental Science and Pollution Research
VL  - 27
IS  - 8
SP  - 7934-7942
EP  - 7934-7942
PB  - Springer Heidelberg
SN  - 09441344
KW  - Nitinol
KW  - Cell
KW  - Biocompatibility
KW  - Biomaterial
KW  - Hydrogen modification
UR  - https://link.springer.com/article/10.1007/s11356-019-07506-8
L2  - https://link.springer.com/article/10.1007/s11356-019-07506-8
N2  - Nickel-titanium alloys have been used in medical applications for several years; however, biocompatibility of the material remains controversial. In the present study, the human umbilical vein endothelial cells (HUVEC) were cultured in contact with the nitinol used in two different heat treatment surface modifications-helium and hydrogen. The amount of Ni ions released from these alloys in contact with HUVEC was measured in media and in the cells by ICP-MS. An increased release of Ni ions was detected in He alloy compared with H-2 alloy modification with an elevation with the metal exposition duration (24 h vs. 72 h). The cells contained the Ni ions in both selected alloy modifications with the lower levels in H-2 alloys. To evaluate the potential of multiple metal applications, similar values were observed in media and in cell suspension for all surface modification combinations. The model analysis of effect of metal ion release on distant cells in the body showed that the concentration is interestingly similar to concentrations in cells in direct contact with the metal alloy. The cells are able to regulate the concentration of Ni ions within the cell. According to our best knowledge, the study for the first time describes the presence of Ni ions released from nitinol directly in the cells. In the case of the H-2 modification, the lowest levels of Ni ions were detected both in medium and in the cells, which likely increases the biocompatibility of the nitinol alloy.
ER  -

VEVERKOVÁ, Jana, Denisa BARTKOVA, Adam WEISER, Antonin DLOUHY, Petr BABULA, Petr ŠTĚPKA and Monika PÁVKOVÁ GOLDBERGOVÁ. Effect of Ni ion release on the cells in contact with NiTi alloys. \textit{Environmental Science and Pollution Research}. Heidelberg: Springer Heidelberg, 2020, vol.~27, No~8, p.~7934-7942. ISSN~0944-1344. Available from: https://dx.doi.org/10.1007/s11356-019-07506-8.

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