HYZD'ALOVA, M., Jiřina HOFMANOVÁ, Jiří PACHERNÍK, Alena HYRŠLOVÁ VACULOVÁ a Alois KOZUBÍK. The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappa B activation. Cytokine. Academic Press, roč. 44, č. 1, s. 33-43. ISSN 1043-4666. doi:10.1016/j.cyto.2008.06.003. 2008.
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Základní údaje
Originální název The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappa B activation
Autoři HYZD'ALOVA, M., Jiřina HOFMANOVÁ (203 Česká republika), Jiří PACHERNÍK (203 Česká republika, domácí), Alena HYRŠLOVÁ VACULOVÁ (203 Česká republika) a Alois KOZUBÍK (203 Česká republika, garant).
Vydání Cytokine, Academic Press, 2008, 1043-4666.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 10608 Biochemistry and molecular biology
Stát vydavatele Velká Británie a Severní Irsko
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 2.214
Organizační jednotka Přírodovědecká fakulta
Doi http://dx.doi.org/10.1016/j.cyto.2008.06.003
UT WoS 000260700600007
Klíčová slova anglicky Butyrate; TNF-alpha; Differentiation; Apoptosis; NF-kappa B
Štítky rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Mgr. Marie Šípková, DiS., učo 437722. Změněno: 16. 6. 2020 11:07.
Anotace
We demonstrated that TNF-alpha suppressed differentiation and potentiated cell death induced by butyrate (NaBt) in both adenocarcinoma HT-29 and fetal FHC human colon cells in vitro. Since TNF-alpha is a typical activator of NF-kappa B pathway, we studied the role of NF-kappa B activation in cell differentiation and death during the TNF-alpha and NaBt co-treatment. TNF-alpha induced rapid NF-kappa B activation in both HT-29 and FHC cell lines and this effect was differently modulated by NaBt in these two cell lines. In HT-29 cells, NaBt potentiated NF-kappa B activity induced by TNF-alpha after 4 h treatment. However, this initial potentiation of NF-kappa B activity was not observed in FHC cells. During additional time of TNF-alpha and NaBt co-treatment, NaBt decreased the TNF-alpha-mediated NF-kappa B activity in both cell types. We also detected a different response of HT-29 and FHC cells after the pre-treatment with the NF-kappa B inhibitor parthenolide. Our results indicated that NaBt-mediated differentiation and apoptosis of colon epithelial cells can be modulated by TNF-alpha. Furthermore, we found significant differences in the mechanism of the NaBt and TNF-alpha co-treatment effects between cells of non-cancer and cancer origin, suggesting that the NF-kappa B pathway may be more effectively involved in these processes in cancer cells.
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