| HYZD'ALOVA, M., Jiřina HOFMANOVÁ, Jiří PACHERNÍK, Alena HYRŠLOVÁ VACULOVÁ and Alois KOZUBÍK. The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappa B activation. Cytokine. Academic Press, 2008, vol. 44, No 1, p. 33-43. ISSN 1043-4666. Available from: https://dx.doi.org/10.1016/j.cyto.2008.06.003. |
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@article{1662617,
author = {Hyzd'alova, M. and Hofmanová, Jiřina and Pacherník, Jiří and Hyršlová Vaculová, Alena and Kozubík, Alois},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.cyto.2008.06.003},
keywords = {Butyrate; TNF-alpha; Differentiation; Apoptosis; NF-kappa B},
language = {eng},
issn = {1043-4666},
journal = {Cytokine},
title = {The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappa B activation},
url = {https://doi.org/10.1016/j.cyto.2008.06.003},
volume = {44},
year = {2008}
}
TY - JOUR
ID - 1662617
AU - Hyzd'alova, M. - Hofmanová, Jiřina - Pacherník, Jiří - Hyršlová Vaculová, Alena - Kozubík, Alois
PY - 2008
TI - The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappa B activation
JF - Cytokine
VL - 44
IS - 1
SP - 33-43
EP - 33-43
PB - Academic Press
SN - 10434666
KW - Butyrate
KW - TNF-alpha
KW - Differentiation
KW - Apoptosis
KW - NF-kappa B
UR - https://doi.org/10.1016/j.cyto.2008.06.003
L2 - https://doi.org/10.1016/j.cyto.2008.06.003
N2 - We demonstrated that TNF-alpha suppressed differentiation and potentiated cell death induced by butyrate (NaBt) in both adenocarcinoma HT-29 and fetal FHC human colon cells in vitro. Since TNF-alpha is a typical activator of NF-kappa B pathway, we studied the role of NF-kappa B activation in cell differentiation and death during the TNF-alpha and NaBt co-treatment. TNF-alpha induced rapid NF-kappa B activation in both HT-29 and FHC cell lines and this effect was differently modulated by NaBt in these two cell lines. In HT-29 cells, NaBt potentiated NF-kappa B activity induced by TNF-alpha after 4 h treatment. However, this initial potentiation of NF-kappa B activity was not observed in FHC cells. During additional time of TNF-alpha and NaBt co-treatment, NaBt decreased the TNF-alpha-mediated NF-kappa B activity in both cell types. We also detected a different response of HT-29 and FHC cells after the pre-treatment with the NF-kappa B inhibitor parthenolide. Our results indicated that NaBt-mediated differentiation and apoptosis of colon epithelial cells can be modulated by TNF-alpha. Furthermore, we found significant differences in the mechanism of the NaBt and TNF-alpha co-treatment effects between cells of non-cancer and cancer origin, suggesting that the NF-kappa B pathway may be more effectively involved in these processes in cancer cells.
ER -
HYZD'ALOVA, M., Jiřina HOFMANOVÁ, Jiří PACHERNÍK, Alena HYRŠLOVÁ VACULOVÁ and Alois KOZUBÍK. The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappa B activation. \textit{Cytokine}. Academic Press, 2008, vol.~44, No~1, p.~33-43. ISSN~1043-4666. Available from: https://dx.doi.org/10.1016/j.cyto.2008.06.003.
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