| KRATOCHVÍLOVÁ, Adéla, Barbora VESELÁ, Vojtěch LEDVINA, Eva ŠVANDOVÁ, Karel KLEPÁRNÍK, Kateřina DADÁKOVÁ, Petr BENEŠ and Eva MATALOVÁ. Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells. Scientific Reports. London: Nature Publishing Group, 2020, vol. 10, No 1, p. 1-8. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-64294-9. |
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@article{1668304,
author = {Kratochvílová, Adéla and Veselá, Barbora and Ledvina, Vojtěch and Švandová, Eva and Klepárník, Karel and Dadáková, Kateřina and Beneš, Petr and Matalová, Eva},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-020-64294-9},
keywords = {Bone; Bone development; Cell biology; Proteases},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells},
url = {https://www.nature.com/articles/s41598-020-64294-9},
volume = {10},
year = {2020}
}
TY - JOUR
ID - 1668304
AU - Kratochvílová, Adéla - Veselá, Barbora - Ledvina, Vojtěch - Švandová, Eva - Klepárník, Karel - Dadáková, Kateřina - Beneš, Petr - Matalová, Eva
PY - 2020
TI - Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells
JF - Scientific Reports
VL - 10
IS - 1
SP - 1-8
EP - 1-8
PB - Nature Publishing Group
SN - 20452322
KW - Bone
KW - Bone development
KW - Cell biology
KW - Proteases
UR - https://www.nature.com/articles/s41598-020-64294-9
L2 - https://www.nature.com/articles/s41598-020-64294-9
N2 - Caspases are proteases traditionally associated with inflammation and cell death. Recently, they have also been shown to modulate cell proliferation and differentiation. The aim of the current research was to search for osteogenic molecules affected by caspase inhibition and to specify the individual caspases critical for these effects with a focus on proapoptotic caspases: caspase-2, -3, -6, -7, -8 and -9. Along with osteocalcin (Ocn), general caspase inhibition significantly decreased the expression of the Phex gene in differentiated MC3T3-E1 cells. The inhibition of individual caspases indicated that caspase-8 is a major contributor to the modification of Ocn and Phex expression. Caspase-2 and-6 had effects on Ocn and caspase-6 had an effect on Phex. These data confirm and expand the current knowledge about the nonapoptotic roles of caspases and the effect of their pharmacological inhibition on the osteogenic potential of osteoblastic cells.
ER -
KRATOCHVÍLOVÁ, Adéla, Barbora VESELÁ, Vojtěch LEDVINA, Eva ŠVANDOVÁ, Karel KLEPÁRNÍK, Kateřina DADÁKOVÁ, Petr BENEŠ and Eva MATALOVÁ. Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells. \textit{Scientific Reports}. London: Nature Publishing Group, 2020, vol.~10, No~1, p.~1-8. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-64294-9.
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