The Emerging Role of Noncoding RNAs in Pediatric Inflammatory
Bowel Disease

J 2020

The Emerging Role of Noncoding RNAs in Pediatric Inflammatory Bowel Disease

JABANDŽIEV, Petr, Júlia BOHOŠOVÁ, Tereza PINKASOVÁ, Lumír KUNOVSKÝ, Ondřej SLABÝ et. al.

Basic information

Original name

The Emerging Role of Noncoding RNAs in Pediatric Inflammatory Bowel Disease

Authors

JABANDŽIEV, Petr (203 Czech Republic, guarantor, belonging to the institution), Júlia BOHOŠOVÁ (703 Slovakia, belonging to the institution), Tereza PINKASOVÁ (203 Czech Republic, belonging to the institution), Lumír KUNOVSKÝ (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and Ajay GOEL (840 United States of America)

Edition

Inflammatory Bowel Diseases, Oxford University Press, 2020, 1078-0998

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30219 Gastroenterology and hepatology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.325

RIV identification code

RIV/00216224:14110/20:00115894

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1093/ibd/izaa009

UT WoS

000544164200014

Keywords in English

pediatrics; inflammatory bowel disease; Crohn’s disease; ulcerative colitis; noncoding RNA; microRNA

Abstract

V originále

Prevalence of inflammatory bowel disease (IBD), a chronic inflammatory disorder of the gut, has been on the rise in recent years—not only in the adult population but also especially in pediatric patients. Despite the absence of curative treatments, current therapeutic options are able to achieve long-term remission in a significant proportion of cases. To this end, however, there is a need for biomarkers enabling accurate diagnosis, prognosis, and prediction of response to therapies to facilitate a more individualized approach to pediatric IBD patients. In recent years, evidence has continued to evolve concerning noncoding RNAs (ncRNAs) and their roles as integral factors in key immune-related cellular pathways. Specific deregulation patterns of ncRNAs have been linked to pathogenesis of various diseases, including pediatric IBD. In this article, we provide an overview of current knowledge on ncRNAs, their altered expression profiles in pediatric IBD patients, and how these are emerging as potentially valuable clinical biomarkers as we enter an era of personalized medicine.

Citovat

JABANDŽIEV, Petr, Júlia BOHOŠOVÁ, Tereza PINKASOVÁ, Lumír KUNOVSKÝ, Ondřej SLABÝ and Ajay GOEL. The Emerging Role of Noncoding RNAs in Pediatric Inflammatory Bowel Disease. Inflammatory Bowel Diseases. Oxford University Press, 2020, vol. 26, No 7, p. 985-993. ISSN 1078-0998. Available from: https://dx.doi.org/10.1093/ibd/izaa009.

@article{1668639,
   author = {Jabandžiev, Petr and Bohošová, Júlia and Pinkasová, Tereza and Kunovský, Lumír and Slabý, Ondřej and Goel, Ajay},
   article_number = {7},
   doi = {http://dx.doi.org/10.1093/ibd/izaa009},
   keywords = {pediatrics; inflammatory bowel disease; Crohn’s disease; ulcerative colitis; noncoding RNA; microRNA},
   language = {eng},
   issn = {1078-0998},
   journal = {Inflammatory Bowel Diseases},
   title = {The Emerging Role of Noncoding RNAs in Pediatric Inflammatory Bowel Disease},
   url = {https://academic.oup.com/ibdjournal/article/26/7/985/5721205},
   volume = {26},
   year = {2020}
}

TY  - JOUR
ID  - 1668639
AU  - Jabandžiev, Petr - Bohošová, Júlia - Pinkasová, Tereza - Kunovský, Lumír - Slabý, Ondřej - Goel, Ajay
PY  - 2020
TI  - The Emerging Role of Noncoding RNAs in Pediatric Inflammatory Bowel Disease
JF  - Inflammatory Bowel Diseases
VL  - 26
IS  - 7
SP  - 985-993
EP  - 985-993
PB  - Oxford University Press
SN  - 10780998
KW  - pediatrics
KW  - inflammatory bowel disease
KW  - Crohn’s disease
KW  - ulcerative colitis
KW  - noncoding RNA
KW  - microRNA
UR  - https://academic.oup.com/ibdjournal/article/26/7/985/5721205
L2  - https://academic.oup.com/ibdjournal/article/26/7/985/5721205
N2  - Prevalence of inflammatory bowel disease (IBD), a chronic inflammatory disorder of the gut, has been on the rise in recent years—not only in the adult population but also especially in pediatric patients. Despite the absence of curative treatments, current therapeutic options are able to achieve long-term remission in a significant proportion of cases. To this end, however, there is a need for biomarkers enabling accurate diagnosis, prognosis, and prediction of response to therapies to facilitate a more individualized approach to pediatric IBD patients. In recent years, evidence has continued to evolve concerning noncoding RNAs (ncRNAs) and their roles as integral factors in key immune-related cellular pathways. Specific deregulation patterns of ncRNAs have been linked to pathogenesis of various diseases, including pediatric IBD. In this article, we provide an overview of current knowledge on ncRNAs, their altered expression profiles in pediatric IBD patients, and how these are emerging as potentially valuable clinical biomarkers as we enter an era of personalized medicine.
ER  -

JABANDŽIEV, Petr, Júlia BOHOŠOVÁ, Tereza PINKASOVÁ, Lumír KUNOVSKÝ, Ondřej SLABÝ and Ajay GOEL. The Emerging Role of Noncoding RNAs in Pediatric Inflammatory Bowel Disease. \textit{Inflammatory Bowel Diseases}. Oxford University Press, 2020, vol.~26, No~7, p.~985-993. ISSN~1078-0998. Available from: https://dx.doi.org/10.1093/ibd/izaa009.

Detailed Information on Publication Record