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@article{1668656,
author = {Suchý, Pavel and Paprskárová, Alice and Chalupová, Marta and Marholdova, Lucie and Nesporova, Kristina and Klusáková, Jarmila and Kuzmínová, Gabriela and Hendrych, Michal and Velebny, Vladimir},
article_location = {ST ALBAN-ANLAGE},
article_number = {7},
doi = {http://dx.doi.org/10.3390/ma13071627},
keywords = {hemostasis; hyaluronic acid; cellulose; etamsylate; nonwoven textile},
language = {eng},
issn = {1996-1944},
journal = {Materials},
title = {Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178357/},
volume = {13},
year = {2020}
}
TY - JOUR
ID - 1668656
AU - Suchý, Pavel - Paprskárová, Alice - Chalupová, Marta - Marholdova, Lucie - Nesporova, Kristina - Klusáková, Jarmila - Kuzmínová, Gabriela - Hendrych, Michal - Velebny, Vladimir
PY - 2020
TI - Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate
JF - Materials
VL - 13
IS - 7
SP - 1-14
EP - 1-14
PB - MDPI
SN - 19961944
KW - hemostasis
KW - hyaluronic acid
KW - cellulose
KW - etamsylate
KW - nonwoven textile
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178357/
L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178357/
N2 - The achievement of rapid hemostasis represents a long-term trend in hemostatic research. Specifically, composite materials are now the focus of attention, based on the given issues and required properties. In urology, different materials are used to achieve fast and effective hemostasis. Additionally, it is desirable to exert a positive influence on local tissue reaction. In this study, three nonwoven textiles prepared by a wet spinning method and based on a combination of hyaluronic acid with either oxidized cellulose or carboxymethyl cellulose, along with the addition of etamsylate, were introduced and assessed in vivo using the rat partial nephrectomy model. A significantly shorter time to hemostasis in seconds (p < 0.05), was attributed to the effect of the carboxymethyl cellulose material. The addition of etamsylate did not noticeably contribute to further hemostasis, but its application strengthened the structure and therefore significantly improved the effect on local changes, while also facilitating any manipulation by the surgeons. Specifically, the hyaluronic acid supported the tissue healing and regeneration, and ensured the favorable results of the histological analysis. Moreover, the prepared textiles proved their bioresorbability after a three-day period. In brief, the fabrics yielded favorable hemostatic activity, bioresorbability, non-irritability, and had a beneficial effect on the tissue repair.
ER -
SUCHÝ, Pavel, Alice PAPRSKÁROVÁ, Marta CHALUPOVÁ, Lucie MARHOLDOVA, Kristina NESPOROVA, Jarmila KLUSÁKOVÁ, Gabriela KUZMÍNOVÁ, Michal HENDRYCH and Vladimir VELEBNY. Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate. \textit{Materials}. ST ALBAN-ANLAGE: MDPI, 2020, vol.~13, No~7, p.~1-14. ISSN~1996-1944. Available from: https://dx.doi.org/10.3390/ma13071627.
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