Composite Hemostatic Nonwoven Textiles Based on Hyaluronic
Acid, Cellulose, and Etamsylate

J 2020

Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate

SUCHÝ, Pavel, Alice PAPRSKÁROVÁ, Marta CHALUPOVÁ, Lucie MARHOLDOVA, Kristina NESPOROVA et. al.

Basic information

Original name

Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate

Authors

SUCHÝ, Pavel (203 Czech Republic, belonging to the institution), Alice PAPRSKÁROVÁ (203 Czech Republic, guarantor), Marta CHALUPOVÁ (203 Czech Republic, belonging to the institution), Lucie MARHOLDOVA (203 Czech Republic), Kristina NESPOROVA (203 Czech Republic), Jarmila KLUSÁKOVÁ (203 Czech Republic, belonging to the institution), Gabriela KUZMÍNOVÁ (203 Czech Republic, belonging to the institution), Michal HENDRYCH (203 Czech Republic, belonging to the institution) and Vladimir VELEBNY (203 Czech Republic)

Edition

Materials, ST ALBAN-ANLAGE, MDPI, 2020, 1996-1944

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.623

RIV identification code

RIV/00216224:14160/20:00115895

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/ma13071627

UT WoS

000529875600145

Keywords in English

hemostasis; hyaluronic acid; cellulose; etamsylate; nonwoven textile

Abstract

V originále

The achievement of rapid hemostasis represents a long-term trend in hemostatic research. Specifically, composite materials are now the focus of attention, based on the given issues and required properties. In urology, different materials are used to achieve fast and effective hemostasis. Additionally, it is desirable to exert a positive influence on local tissue reaction. In this study, three nonwoven textiles prepared by a wet spinning method and based on a combination of hyaluronic acid with either oxidized cellulose or carboxymethyl cellulose, along with the addition of etamsylate, were introduced and assessed in vivo using the rat partial nephrectomy model. A significantly shorter time to hemostasis in seconds (p < 0.05), was attributed to the effect of the carboxymethyl cellulose material. The addition of etamsylate did not noticeably contribute to further hemostasis, but its application strengthened the structure and therefore significantly improved the effect on local changes, while also facilitating any manipulation by the surgeons. Specifically, the hyaluronic acid supported the tissue healing and regeneration, and ensured the favorable results of the histological analysis. Moreover, the prepared textiles proved their bioresorbability after a three-day period. In brief, the fabrics yielded favorable hemostatic activity, bioresorbability, non-irritability, and had a beneficial effect on the tissue repair.

Citovat

SUCHÝ, Pavel, Alice PAPRSKÁROVÁ, Marta CHALUPOVÁ, Lucie MARHOLDOVA, Kristina NESPOROVA, Jarmila KLUSÁKOVÁ, Gabriela KUZMÍNOVÁ, Michal HENDRYCH and Vladimir VELEBNY. Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate. Materials. ST ALBAN-ANLAGE: MDPI, 2020, vol. 13, No 7, p. 1-14. ISSN 1996-1944. Available from: https://dx.doi.org/10.3390/ma13071627.

@article{1668656,
   author = {Suchý, Pavel and Paprskárová, Alice and Chalupová, Marta and Marholdova, Lucie and Nesporova, Kristina and Klusáková, Jarmila and Kuzmínová, Gabriela and Hendrych, Michal and Velebny, Vladimir},
   article_location = {ST ALBAN-ANLAGE},
   article_number = {7},
   doi = {http://dx.doi.org/10.3390/ma13071627},
   keywords = {hemostasis; hyaluronic acid; cellulose; etamsylate; nonwoven textile},
   language = {eng},
   issn = {1996-1944},
   journal = {Materials},
   title = {Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate},
   url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178357/},
   volume = {13},
   year = {2020}
}

TY  - JOUR
ID  - 1668656
AU  - Suchý, Pavel - Paprskárová, Alice - Chalupová, Marta - Marholdova, Lucie - Nesporova, Kristina - Klusáková, Jarmila - Kuzmínová, Gabriela - Hendrych, Michal - Velebny, Vladimir
PY  - 2020
TI  - Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate
JF  - Materials
VL  - 13
IS  - 7
SP  - 1-14
EP  - 1-14
PB  - MDPI
SN  - 19961944
KW  - hemostasis
KW  - hyaluronic acid
KW  - cellulose
KW  - etamsylate
KW  - nonwoven textile
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178357/
L2  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178357/
N2  - The achievement of rapid hemostasis represents a long-term trend in hemostatic research. Specifically, composite materials are now the focus of attention, based on the given issues and required properties. In urology, different materials are used to achieve fast and effective hemostasis. Additionally, it is desirable to exert a positive influence on local tissue reaction. In this study, three nonwoven textiles prepared by a wet spinning method and based on a combination of hyaluronic acid with either oxidized cellulose or carboxymethyl cellulose, along with the addition of etamsylate, were introduced and assessed in vivo using the rat partial nephrectomy model. A significantly shorter time to hemostasis in seconds (p < 0.05), was attributed to the effect of the carboxymethyl cellulose material. The addition of etamsylate did not noticeably contribute to further hemostasis, but its application strengthened the structure and therefore significantly improved the effect on local changes, while also facilitating any manipulation by the surgeons. Specifically, the hyaluronic acid supported the tissue healing and regeneration, and ensured the favorable results of the histological analysis. Moreover, the prepared textiles proved their bioresorbability after a three-day period. In brief, the fabrics yielded favorable hemostatic activity, bioresorbability, non-irritability, and had a beneficial effect on the tissue repair.
ER  -

SUCHÝ, Pavel, Alice PAPRSKÁROVÁ, Marta CHALUPOVÁ, Lucie MARHOLDOVA, Kristina NESPOROVA, Jarmila KLUSÁKOVÁ, Gabriela KUZMÍNOVÁ, Michal HENDRYCH and Vladimir VELEBNY. Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate. \textit{Materials}. ST ALBAN-ANLAGE: MDPI, 2020, vol.~13, No~7, p.~1-14. ISSN~1996-1944. Available from: https://dx.doi.org/10.3390/ma13071627.

Detailed Information on Publication Record