HORÁKOVÁ, Magda, Tomáš HORÁK, Josef BEDNAŘÍK and Stanislav VOHÁŇKA. The Association of methylprednisolone dosing to cessation of myotonia in a patient with myotonic dystrophy type 1. Neuromuscular Disorders. London: Elsevier, 2020, vol. 30, No 5, p. 427-430. ISSN 0960-8966. Available from: https://dx.doi.org/10.1016/j.nmd.2020.03.004.
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Basic information
Original name The Association of methylprednisolone dosing to cessation of myotonia in a patient with myotonic dystrophy type 1
Authors HORÁKOVÁ, Magda (203 Czech Republic, belonging to the institution), Tomáš HORÁK (203 Czech Republic, guarantor, belonging to the institution), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution) and Stanislav VOHÁŇKA (203 Czech Republic, belonging to the institution).
Edition Neuromuscular Disorders, London, Elsevier, 2020, 0960-8966.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30103 Neurosciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.296
RIV identification code RIV/00216224:14110/20:00115973
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.nmd.2020.03.004
UT WoS 000539369800009
Keywords in English Myotonia; Myotonic dystrophy; Methylprednisolone; Corticosteroids; Muscle relaxation; Therapy
Tags 14110221, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 12/5/2021 13:11.
Abstract
We report the case of a patient suffering from duplicity of myotonic dystrophy type 1 and ulcerative colitis whose treatment for ulcerative colitis included repeated administrations of descending doses of methylprednisolone and in whom we found an association between methylprednisolone dosing and cessation of myotonia. Myotonia severity was expressed as relaxation time after voluntary contraction and as a patient-reported outcome using the Czech version of the Myotonia Behavior Scale. The patient was being treated for a flare of ulcerative colitis, starting with 32 mg of methylprednisolone and reducing the dose by 4 mg a week. The symptoms of myotonia began to wear off three weeks after starting methylprednisolone and had totally disappeared by four weeks after starting methylprednisolone. The first symptoms of myotonia returned about a month after the last dose of methylprednisolone and reached a peak of severity more than two months after the final dose. (C) 2020 Elsevier B.V. All rights reserved.
Links
MUNI/A/1325/2019, interní kód MUName: Diagnostika a patofyziologie neuropatické bolesti (Acronym: PNB)
Investor: Masaryk University, Category A
MUNI/A/1419/2018, interní kód MUName: Diagnostika a patofyziologie neuropatické bolesti (Acronym: PNB)
Investor: Masaryk University, Category A
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