J 2020

Mussel-mimicking sulfobetaine-based copolymer with metal tunable gelation, self-healing and antibacterial capability

MRLIK, M., Mário ŠPÍREK, J. AL-KHORI, A. A. AHMAD, J. MOSNACEK et. al.

Basic information

Original name

Mussel-mimicking sulfobetaine-based copolymer with metal tunable gelation, self-healing and antibacterial capability

Authors

MRLIK, M. (203 Czech Republic, guarantor), Mário ŠPÍREK (703 Slovakia, belonging to the institution), J. AL-KHORI (634 Qatar), A. A. AHMAD (634 Qatar), J. MOSNACEK (703 Slovakia), M. A. ALMAADEED (634 Qatar) and P. KASAK (634 Qatar)

Edition

Arabian Journal of Chemistry, Amsterdam, ELSEVIER, 2020, 1878-5352

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10404 Polymer science

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 5.165

RIV identification code

RIV/00216224:14110/20:00115979

Organization unit

Faculty of Medicine

DOI

UT WoS

000505076000018

Keywords in English

Polysulfobetaine; Metal coordination; Antibacterial; Self-healing; Hydrogels; Catecholamine polymers

Tags

Tags

International impact, Reviewed
Změněno: 15/7/2020 08:23, Mgr. Tereza Miškechová

Abstract

V originále

In the present study, the sulfobetaine-based copolymer bearing a dopamine functionality showed gel formation adjusted by the application of metal salts for gelation and various values of pH. Normally, the liquid-like solution of the sulfobetaine-based copolymer and metal cross-linkers is transformed to a gel-like state upon increasing the pH values in the presence of Fe3+ and Ti3+. Metal-induced coordination is reversible by means of the application of EDTA as a chelating agent. In the case of Ag+ ions, the gel is formed through a redox process accompanied with the oxidative coupling of the dopamine moieties and Ag-0 particle formation. Mussel-mimicking and metal-dependent viscoelastic properties were observed for Fe3+, Ti3+, and Ag+ cross-linking agents, with additionally enhanced self-healing behavior in comparison with the covalently cross-linked IO4- analogues. Antibacterial properties can be achieved both in solution and on the surface using the proper concentration of Ag+ ions used for gelation; thus, a tunable amount of the Ag-0 particles are formed in the hydrogel. The cytotoxicity was elucidated by the both MTT assay on the NIH/3T3 fibroblast cell line and direct contact method using human dermal fibroblast cell (F121) and shows the non-toxic character of the synthesized copolymer. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.