Rotating frame MRI relaxations as markers of diffuse white
matter abnormalities in multiple sclerosis

J 2020

Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis

FILIP, Pavel, Alena SVATKOVA, Adam F. CARPENTER, Lynn E. EBERLY, Igor NESTRASIL et. al.

Basic information

Original name

Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis

Authors

FILIP, Pavel (703 Slovakia, belonging to the institution), Alena SVATKOVA (203 Czech Republic), Adam F. CARPENTER (840 United States of America), Lynn E. EBERLY (840 United States of America), Igor NESTRASIL (203 Czech Republic), Mikko J. NISSI (246 Finland), Shalom MICHAELI (840 United States of America) and Silvia MANGIA (840 United States of America, guarantor)

Edition

NeuroImage: Clinical, Oxford, Elsevier BV, 2020, 2213-1582

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.881

RIV identification code

RIV/00216224:14110/20:00115980

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.nicl.2020.102234

UT WoS

000533149400052

Keywords in English

Multiple sclerosis; Rotating frame relaxation MRI; Adiabatic pulses; DTI; T1w/T2w ratio

Abstract

V originále

Even though MRI visualization of white matter lesions is pivotal for the diagnosis and management of multiple sclerosis (MS), the issue of detecting diffuse brain tissue damage beyond the apparent T2-hyperintense lesions continues to spark considerable interest. Motivated by the notion that rotating frame MRI methods are sensitive to slow motional regimes critical for tissue characterization, here we utilized novel imaging protocols of rotating frame MRI on a clinical 3 Tesla platform, including adiabatic longitudinal, T1 rho, and transverse, T2 rho, relaxation methods, and Relaxation Along a Fictitious Field (RAFF) in the rotating frame of rank 4 (RAFF4), in 10 relapsing-remitting multiple sclerosis patients and 10 sex- and age-matched healthy controls. T1 rho, T2 rho and RAFF4 relaxograms extracted from the whole white matter exhibited a significant shift towards longer relaxation time constants in MS patients as compared to controls. T1 rho and RAFF4 detected alterations even when considering only regions of normally appearing white matter (NAWM), while other MRI metrics such as T1w/T2w ratio and diffusion tensor imaging measures failed to find group differences. In addition, RAFF4, T2 rho and, to a lesser extent, T1 rho showed differences in subcortical grey matter structures, mainly hippocampus, whereas no functional changes in this region were detected in resting-state functional MRI metrics. We conclude that rotating frame MRI techniques are exceptionally sensitive methods for the detection of subtle abnormalities not only in NAWM, but also in deep grey matter in MS, where they surpass even highly sensitive measures of functional changes, which are often suggested to precede detectable structural alterations. Such abnormalities are consistent with a wide spectrum of different, but interconnected pathological features of MS, including the loss of neuronal cells and their axons, decreased levels of myelin even in NAWM, and altered iron content.

Citovat

FILIP, Pavel, Alena SVATKOVA, Adam F. CARPENTER, Lynn E. EBERLY, Igor NESTRASIL, Mikko J. NISSI, Shalom MICHAELI and Silvia MANGIA. Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis. NeuroImage: Clinical. Oxford: Elsevier BV, 2020, vol. 26, No 2020, p. 1-12. ISSN 2213-1582. Available from: https://dx.doi.org/10.1016/j.nicl.2020.102234.

@article{1670345,
   author = {Filip, Pavel and Svatkova, Alena and Carpenter, Adam F. and Eberly, Lynn E. and Nestrasil, Igor and Nissi, Mikko J. and Michaeli, Shalom and Mangia, Silvia},
   article_location = {Oxford},
   article_number = {2020},
   doi = {http://dx.doi.org/10.1016/j.nicl.2020.102234},
   keywords = {Multiple sclerosis; Rotating frame relaxation MRI; Adiabatic pulses; DTI; T1w/T2w ratio},
   language = {eng},
   issn = {2213-1582},
   journal = {NeuroImage: Clinical},
   title = {Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis},
   url = {https://www.sciencedirect.com/science/article/pii/S2213158220300711?via%3Dihub},
   volume = {26},
   year = {2020}
}

TY  - JOUR
ID  - 1670345
AU  - Filip, Pavel - Svatkova, Alena - Carpenter, Adam F. - Eberly, Lynn E. - Nestrasil, Igor - Nissi, Mikko J. - Michaeli, Shalom - Mangia, Silvia
PY  - 2020
TI  - Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis
JF  - NeuroImage: Clinical
VL  - 26
IS  - 2020
SP  - 1-12
EP  - 1-12
PB  - Elsevier BV
SN  - 22131582
KW  - Multiple sclerosis
KW  - Rotating frame relaxation MRI
KW  - Adiabatic pulses
KW  - DTI
KW  - T1w/T2w ratio
UR  - https://www.sciencedirect.com/science/article/pii/S2213158220300711?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S2213158220300711?via%3Dihub
N2  - Even though MRI visualization of white matter lesions is pivotal for the diagnosis and management of multiple sclerosis (MS), the issue of detecting diffuse brain tissue damage beyond the apparent T2-hyperintense lesions continues to spark considerable interest. Motivated by the notion that rotating frame MRI methods are sensitive to slow motional regimes critical for tissue characterization, here we utilized novel imaging protocols of rotating frame MRI on a clinical 3 Tesla platform, including adiabatic longitudinal, T1 rho, and transverse, T2 rho, relaxation methods, and Relaxation Along a Fictitious Field (RAFF) in the rotating frame of rank 4 (RAFF4), in 10 relapsing-remitting multiple sclerosis patients and 10 sex- and age-matched healthy controls. T1 rho, T2 rho and RAFF4 relaxograms extracted from the whole white matter exhibited a significant shift towards longer relaxation time constants in MS patients as compared to controls. T1 rho and RAFF4 detected alterations even when considering only regions of normally appearing white matter (NAWM), while other MRI metrics such as T1w/T2w ratio and diffusion tensor imaging measures failed to find group differences. In addition, RAFF4, T2 rho and, to a lesser extent, T1 rho showed differences in subcortical grey matter structures, mainly hippocampus, whereas no functional changes in this region were detected in resting-state functional MRI metrics. We conclude that rotating frame MRI techniques are exceptionally sensitive methods for the detection of subtle abnormalities not only in NAWM, but also in deep grey matter in MS, where they surpass even highly sensitive measures of functional changes, which are often suggested to precede detectable structural alterations. Such abnormalities are consistent with a wide spectrum of different, but interconnected pathological features of MS, including the loss of neuronal cells and their axons, decreased levels of myelin even in NAWM, and altered iron content.
ER  -

FILIP, Pavel, Alena SVATKOVA, Adam F. CARPENTER, Lynn E. EBERLY, Igor NESTRASIL, Mikko J. NISSI, Shalom MICHAELI and Silvia MANGIA. Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis. \textit{NeuroImage: Clinical}. Oxford: Elsevier BV, 2020, vol.~26, No~2020, p.~1-12. ISSN~2213-1582. Available from: https://dx.doi.org/10.1016/j.nicl.2020.102234.

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