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@article{1670356, author = {Qaradakhi, T. and Gadanec, L. K. and McSweeney, K. R. and Tacey, A. and Apostolopoulos, V. and Levinger, I. and Rimarova, K. and Egom, E. E. and Rodrigo, L. and Kružliak, Peter and Kubatka, P. and Zulli, A.}, article_location = {Australia}, article_number = {5}, doi = {http://dx.doi.org/10.1111/1440-1681.13251}, keywords = {angiotensin-converting enzyme II; cardiovascular disease; diminazene aceturate; endothelial dysfunction; renin angiotensin system}, language = {eng}, issn = {0305-1870}, journal = {Clinical and Experimental Pharmacology and Physiology}, title = {The potential actions of angiotensin-converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases}, url = {https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13251}, volume = {47}, year = {2020} }
TY - JOUR ID - 1670356 AU - Qaradakhi, T. - Gadanec, L. K. - McSweeney, K. R. - Tacey, A. - Apostolopoulos, V. - Levinger, I. - Rimarova, K. - Egom, E. E. - Rodrigo, L. - Kružliak, Peter - Kubatka, P. - Zulli, A. PY - 2020 TI - The potential actions of angiotensin-converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases JF - Clinical and Experimental Pharmacology and Physiology VL - 47 IS - 5 SP - 751-758 EP - 751-758 PB - Blackwell Publishing Australia SN - 03051870 KW - angiotensin-converting enzyme II KW - cardiovascular disease KW - diminazene aceturate KW - endothelial dysfunction KW - renin angiotensin system UR - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13251 L2 - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13251 N2 - The renin angiotensin system (RAS) regulates fluid balance, blood pressure and maintains vascular tone. The potent vasoconstrictor angiotensin II (Ang II) produced by angiotensin-converting enzyme (ACE) comprises the classical RAS. The non-classical RAS involves the conversion of Ang II via ACE2 into the vasodilator Ang (1-7) to counterbalance the effects of Ang II. Furthermore, ACE2 converts AngA into another vasodilator named alamandine. The over activation of the classical RAS (increased vasoconstriction) and depletion of the non-classical RAS (decreased vasodilation) results in vascular dysfunction. Vascular dysfunction is the leading cause of atherosclerosis and cardiovascular disease (CVD). Additionally, local RAS is expressed in various tissues and regulates cellular functions. RAS dysregulation is involved in other several diseases such as inflammation, renal dysfunction and even cancer growth. An approach in restoring vascular dysfunction and other pathological diseases is to either increase the activity of ACE2 or reduce the effect of the classical RAS by counterbalancing Ang II effects. The antitrypanosomal agent, diminazene aceturate (DIZE), is one approach in activating ACE2. DIZE has been shown to exert beneficial effects in CVD experimental models of hypertension, myocardial infarction, type 1 diabetes and atherosclerosis. Thus, this review focuses on DIZE and its effect in several tissues such as blood vessels, cardiac, renal, immune and cancer cells. ER -
QARADAKHI, T., L. K. GADANEC, K. R. MCSWEENEY, A. TACEY, V. APOSTOLOPOULOS, I. LEVINGER, K. RIMAROVA, E. E. EGOM, L. RODRIGO, Peter KRUŽLIAK, P. KUBATKA and A. ZULLI. The potential actions of angiotensin-converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases. \textit{Clinical and Experimental Pharmacology and Physiology}. Australia: Blackwell Publishing Australia, 2020, vol.~47, No~5, p.~751-758. ISSN~0305-1870. Available from: https://dx.doi.org/10.1111/1440-1681.13251.
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