Comparison of different methods of thrombus permeability
measurement and impact on recanalization in the INTERRSeCT
multinational multicenter prospective cohort study

J 2020

Comparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERRSeCT multinational multicenter prospective cohort study

GENSICKE, H., J. W. EVANS, F. S. AL AJLAN, D. DOWLATSHAHI, M. NAJM et. al.

Basic information

Original name

Comparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERRSeCT multinational multicenter prospective cohort study

Authors

GENSICKE, H. (124 Canada, guarantor), J. W. EVANS (124 Canada), F. S. AL AJLAN (124 Canada), D. DOWLATSHAHI (124 Canada), M. NAJM (124 Canada), A. L. CALLEJA (724 Spain), J. PUIG (724 Spain), S .L. SOHN (410 Republic of Korea), S. H. AHN (410 Republic of Korea), A. Y. POPPE (124 Canada), Robert MIKULÍK (203 Czech Republic, belonging to the institution), N. ASDAGHI (840 United States of America), T. S. FIELD (124 Canada), A. JIN (124 Canada), T. ASIL (792 Turkey), J. M. BOULANGER (124 Canada), M. D. HILL (124 Canada), M. GOYAL (124 Canada), A. M. DEMCHUK (124 Canada) and B. K. MENON (124 Canada)

Edition

NEURORADIOLOGY, NEW YORK, SPRINGER, 2020, 0028-3940

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.804

RIV identification code

RIV/00216224:14110/20:00115996

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s00234-019-02320-y

UT WoS

000495942400003

Keywords in English

Acute ischemic stroke; Thrombus permeability; Recanalization therapies; NCCT; CTA

Abstract

V originále

Purpose To compare the association of different measures of intracranial thrombus permeability on non-contrast computerized tomography (NCCT) and computed tomography angiography (CTA) with recanalization with or without intravenous alteplase. Methods Patients with anterior circulation occlusion from the INTERRSeCT study were included. Thrombus permeability was measured on non-contrast CT and CTA using the following methods: [1] automated method, mean attenuation increase on co-registered thin (< 2.5 mm) CTA/NCCT; [2] semi-automated method, maximum attenuation increase on non-registered CTA/NCCT (Delta HUmax); [3] manual method, maximum attenuation on CTA (HUmax); and [4] visual method, residual flow grade. Primary outcome was recanalization with intravenous alteplase on the revised AOL scale (2b/3). Regression models were compared using C-statistic, Akaike (AIC), and Bayesian information criterion (BIC). Results Four hundred eighty patients were included in this analysis. Statistical models using methods 2, 3, and 4 were similar in their ability to discriminate recanalizers from non-recanalizers (C-statistic 0.667, 0.683, and 0.634, respectively); method 3 had the least information loss (AIC = 483.8; BIC = 492.2). A HUmax >= 89 measured with method 3 provided optimal sensitivity and specificity in discriminating recanalizers from non-recanalizers [recanalization 55.4% (95%CI 46.2-64.6) when HUmax > 89 vs. 16.8% (95%CI 13.0-20.6) when HUmax <= 89]. In sensitivity analyses restricted to patients with co-registered CTA/NCCT (n = 88), methods 1-4 predicted recanalization similarly (C-statistic 0.641, 0.688, 0.640, 0.648, respectively) with Method 2 having the least information loss (AIC 104.8, BIC 109.8). Conclusion Simple methods that measure thrombus permeability are as reliable as complex image processing methods in discriminating recanalizers from non-recanalizers.

Citovat

GENSICKE, H., J. W. EVANS, F. S. AL AJLAN, D. DOWLATSHAHI, M. NAJM, A. L. CALLEJA, J. PUIG, S .L. SOHN, S. H. AHN, A. Y. POPPE, Robert MIKULÍK, N. ASDAGHI, T. S. FIELD, A. JIN, T. ASIL, J. M. BOULANGER, M. D. HILL, M. GOYAL, A. M. DEMCHUK and B. K. MENON. Comparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERRSeCT multinational multicenter prospective cohort study. NEURORADIOLOGY. NEW YORK: SPRINGER, 2020, vol. 62, No 3, p. 301-306. ISSN 0028-3940. Available from: https://dx.doi.org/10.1007/s00234-019-02320-y.

@article{1670384,
   author = {Gensicke, H. and Evans, J. W. and Al Ajlan, F. S. and Dowlatshahi, D. and Najm, M. and Calleja, A. L. and Puig, J. and Sohn, S .L. and Ahn, S. H. and Poppe, A. Y. and Mikulík, Robert and Asdaghi, N. and Field, T. S. and Jin, A. and Asil, T. and Boulanger, J. M. and Hill, M. D. and Goyal, M. and Demchuk, A. M. and Menon, B. K.},
   article_location = {NEW YORK},
   article_number = {3},
   doi = {http://dx.doi.org/10.1007/s00234-019-02320-y},
   keywords = {Acute ischemic stroke; Thrombus permeability; Recanalization therapies; NCCT; CTA},
   language = {eng},
   issn = {0028-3940},
   journal = {NEURORADIOLOGY},
   title = {Comparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERRSeCT multinational multicenter prospective cohort study},
   url = {https://link.springer.com/article/10.1007%2Fs00234-019-02320-y},
   volume = {62},
   year = {2020}
}

TY  - JOUR
ID  - 1670384
AU  - Gensicke, H. - Evans, J. W. - Al Ajlan, F. S. - Dowlatshahi, D. - Najm, M. - Calleja, A. L. - Puig, J. - Sohn, S .L. - Ahn, S. H. - Poppe, A. Y. - Mikulík, Robert - Asdaghi, N. - Field, T. S. - Jin, A. - Asil, T. - Boulanger, J. M. - Hill, M. D. - Goyal, M. - Demchuk, A. M. - Menon, B. K.
PY  - 2020
TI  - Comparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERRSeCT multinational multicenter prospective cohort study
JF  - NEURORADIOLOGY
VL  - 62
IS  - 3
SP  - 301-306
EP  - 301-306
PB  - SPRINGER
SN  - 00283940
KW  - Acute ischemic stroke
KW  - Thrombus permeability
KW  - Recanalization therapies
KW  - NCCT
KW  - CTA
UR  - https://link.springer.com/article/10.1007%2Fs00234-019-02320-y
L2  - https://link.springer.com/article/10.1007%2Fs00234-019-02320-y
N2  - Purpose To compare the association of different measures of intracranial thrombus permeability on non-contrast computerized tomography (NCCT) and computed tomography angiography (CTA) with recanalization with or without intravenous alteplase. Methods Patients with anterior circulation occlusion from the INTERRSeCT study were included. Thrombus permeability was measured on non-contrast CT and CTA using the following methods: [1] automated method, mean attenuation increase on co-registered thin (< 2.5 mm) CTA/NCCT; [2] semi-automated method, maximum attenuation increase on non-registered CTA/NCCT (Delta HUmax); [3] manual method, maximum attenuation on CTA (HUmax); and [4] visual method, residual flow grade. Primary outcome was recanalization with intravenous alteplase on the revised AOL scale (2b/3). Regression models were compared using C-statistic, Akaike (AIC), and Bayesian information criterion (BIC). Results Four hundred eighty patients were included in this analysis. Statistical models using methods 2, 3, and 4 were similar in their ability to discriminate recanalizers from non-recanalizers (C-statistic 0.667, 0.683, and 0.634, respectively); method 3 had the least information loss (AIC = 483.8; BIC = 492.2). A HUmax >= 89 measured with method 3 provided optimal sensitivity and specificity in discriminating recanalizers from non-recanalizers [recanalization 55.4% (95%CI 46.2-64.6) when HUmax > 89 vs. 16.8% (95%CI 13.0-20.6) when HUmax <= 89]. In sensitivity analyses restricted to patients with co-registered CTA/NCCT (n = 88), methods 1-4 predicted recanalization similarly (C-statistic 0.641, 0.688, 0.640, 0.648, respectively) with Method 2 having the least information loss (AIC 104.8, BIC 109.8). Conclusion Simple methods that measure thrombus permeability are as reliable as complex image processing methods in discriminating recanalizers from non-recanalizers.
ER  -

GENSICKE, H., J. W. EVANS, F. S. AL AJLAN, D. DOWLATSHAHI, M. NAJM, A. L. CALLEJA, J. PUIG, S .L. SOHN, S. H. AHN, A. Y. POPPE, Robert MIKULÍK, N. ASDAGHI, T. S. FIELD, A. JIN, T. ASIL, J. M. BOULANGER, M. D. HILL, M. GOYAL, A. M. DEMCHUK and B. K. MENON. Comparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERRSeCT multinational multicenter prospective cohort study. \textit{NEURORADIOLOGY}. NEW YORK: SPRINGER, 2020, vol.~62, No~3, p.~301-306. ISSN~0028-3940. Available from: https://dx.doi.org/10.1007/s00234-019-02320-y.

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