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@article{1670416,
author = {Raudenská, Martina and Gumulec, Jaromír and Balvan, Jan and Masařík, Michal},
article_location = {HOBOKEN},
article_number = {7},
doi = {http://dx.doi.org/10.1002/ijc.32987},
keywords = {Caveolin-1; metabolic symbiosis; tumor microenvironment; cancer; metabolism; glycolysis; cancer-associated fibroblast},
language = {eng},
issn = {0020-7136},
journal = {International journal of cancer},
title = {Caveolin-1 in oncogenic metabolic symbiosis},
url = {https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32987},
volume = {147},
year = {2020}
}
TY - JOUR
ID - 1670416
AU - Raudenská, Martina - Gumulec, Jaromír - Balvan, Jan - Masařík, Michal
PY - 2020
TI - Caveolin-1 in oncogenic metabolic symbiosis
JF - International journal of cancer
VL - 147
IS - 7
SP - 1793-1807
EP - 1793-1807
PB - International Union Against Cancer
SN - 00207136
KW - Caveolin-1
KW - metabolic symbiosis
KW - tumor microenvironment
KW - cancer
KW - metabolism
KW - glycolysis
KW - cancer-associated fibroblast
UR - https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32987
L2 - https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32987
N2 - Metabolic phenotypes of cancer cells are heterogeneous and flexible as a tumor mass is a hurriedly evolving system capable of constant adaptation to oxygen and nutrient availability. The exact type of cancer metabolism arises from the combined effects of factors intrinsic to the cancer cells and factors proposed by the tumor microenvironment. As a result, a condition termed oncogenic metabolic symbiosis in which components of the tumor microenvironment (TME) promote tumor growth often occurs. Understanding how oncogenic metabolic symbiosis emerges and evolves is crucial for perceiving tumorigenesis. The process by which tumor cells reprogram their TME involves many mechanisms, including changes in intercellular communication, alterations in metabolic phenotypes of TME cells, and rearrangement of the extracellular matrix. It is possible that one molecule with a pleiotropic effect such as Caveolin-1 may affect many of these pathways. Here, we discuss the significance of Caveolin-1 in establishing metabolic symbiosis in TME.
ER -
RAUDENSKÁ, Martina, Jaromír GUMULEC, Jan BALVAN and Michal MASAŘÍK. Caveolin-1 in oncogenic metabolic symbiosis. \textit{International journal of cancer}. HOBOKEN: International Union Against Cancer, 2020, vol.~147, No~7, p.~1793-1807. ISSN~0020-7136. Available from: https://dx.doi.org/10.1002/ijc.32987.
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