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@article{1670416, author = {Raudenská, Martina and Gumulec, Jaromír and Balvan, Jan and Masařík, Michal}, article_location = {HOBOKEN}, article_number = {7}, doi = {http://dx.doi.org/10.1002/ijc.32987}, keywords = {Caveolin-1; metabolic symbiosis; tumor microenvironment; cancer; metabolism; glycolysis; cancer-associated fibroblast}, language = {eng}, issn = {0020-7136}, journal = {International journal of cancer}, title = {Caveolin-1 in oncogenic metabolic symbiosis}, url = {https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32987}, volume = {147}, year = {2020} }
TY - JOUR ID - 1670416 AU - Raudenská, Martina - Gumulec, Jaromír - Balvan, Jan - Masařík, Michal PY - 2020 TI - Caveolin-1 in oncogenic metabolic symbiosis JF - International journal of cancer VL - 147 IS - 7 SP - 1793-1807 EP - 1793-1807 PB - International Union Against Cancer SN - 00207136 KW - Caveolin-1 KW - metabolic symbiosis KW - tumor microenvironment KW - cancer KW - metabolism KW - glycolysis KW - cancer-associated fibroblast UR - https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32987 L2 - https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32987 N2 - Metabolic phenotypes of cancer cells are heterogeneous and flexible as a tumor mass is a hurriedly evolving system capable of constant adaptation to oxygen and nutrient availability. The exact type of cancer metabolism arises from the combined effects of factors intrinsic to the cancer cells and factors proposed by the tumor microenvironment. As a result, a condition termed oncogenic metabolic symbiosis in which components of the tumor microenvironment (TME) promote tumor growth often occurs. Understanding how oncogenic metabolic symbiosis emerges and evolves is crucial for perceiving tumorigenesis. The process by which tumor cells reprogram their TME involves many mechanisms, including changes in intercellular communication, alterations in metabolic phenotypes of TME cells, and rearrangement of the extracellular matrix. It is possible that one molecule with a pleiotropic effect such as Caveolin-1 may affect many of these pathways. Here, we discuss the significance of Caveolin-1 in establishing metabolic symbiosis in TME. ER -
RAUDENSKÁ, Martina, Jaromír GUMULEC, Jan BALVAN and Michal MASAŘÍK. Caveolin-1 in oncogenic metabolic symbiosis. \textit{International journal of cancer}. HOBOKEN: International Union Against Cancer, 2020, vol.~147, No~7, p.~1793-1807. ISSN~0020-7136. Available from: https://dx.doi.org/10.1002/ijc.32987.
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