KŘIKAVA, Ivo, Martin KOLAR, Barbora GARAJOVA, Tomas BALIK, Alena ŠEVČÍKOVÁ, Ingolf ROSCHKE a Pavel SEVCIK. The efficacy of a non-leaching antibacterial central venous catheter - a prospective, randomized, double-blind study. Biomedical Papers, Olomouc: Palacky University. Olomouc: Palacky University, 2020, roč. 164, č. 2, s. 154-160. ISSN 1213-8118. doi:10.5507/bp.2019.022.
Další formáty:   BibTeX LaTeX RIS
Základní údaje
Originální název The efficacy of a non-leaching antibacterial central venous catheter - a prospective, randomized, double-blind study
Autoři KŘIKAVA, Ivo (203 Česká republika, domácí), Martin KOLAR (203 Česká republika), Barbora GARAJOVA (203 Česká republika), Tomas BALIK (203 Česká republika), Alena ŠEVČÍKOVÁ (203 Česká republika, domácí), Ingolf ROSCHKE (276 Německo) a Pavel SEVCIK (203 Česká republika, garant).
Vydání Biomedical Papers, Olomouc: Palacky University, Olomouc, Palacky University, 2020, 1213-8118.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30223 Anaesthesiology
Stát vydavatele Česká republika
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 1.245
Kód RIV RIV/00216224:14110/20:00116005
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.5507/bp.2019.022
UT WoS 000542635800006
Klíčová slova anglicky antimicrobial; CVC; non-leaching; catheter-related bloodstream infections
Štítky 14110322, 14110616, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Mgr. Tereza Miškechová, učo 341652. Změněno: 16. 7. 2020 10:42.
Anotace
Background. Antimicrobial coatings of central venous catheters (CVC) have the potential to reduce the risk of infectious complications. The aim of this study was to examine the efficacy of a catheter with a non-leaching antimicrobial coating against catheter colonization and bloodstream infections (BSI). Methods. The study was conducted in two centers using a prospective, randomized, double-blind and controlled design (680 intensive care patients; a protective CVC (Certofix (R) protect) or a standard CVC (Certofix (R)). Primary objectives were the rates of catheter colonization and BSI in the two groups. Other baseline demographics, APACHE II score, insertion site, location of CVC placement (ICU or theatre), indwelling time and length of ICU stay were comparable for both groups. Results. While the rate of catheter colonization between the coated and uncoated CVC (17.4% vs. 18.7%, P=0.7477) and the rate of microbiologically confirmed catheter associated infections were similar (1.4% vs. 1.9%, P=0.7521), the coated CVC showed a significantly lower incidence of BSI (2.0% vs. 6.5%, P=0.0081) and a significantly lower mean incidence of BSI per 1000 catheter days (3.2 vs. 8.3, P=0.0356). Conclusion. The non-leaching antibacterial coating of the protective catheter was effective in reducing the incidence of BSI but not the rate of catheter colonization. However, the incidence of BSI is a better surrogate marker for the risk of developing clinical signs of infection suggesting that use of the non-leaching protective catheter is effective in this regard.
VytisknoutZobrazeno: 19. 3. 2024 12:02