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@article{1670502,
author = {Solár, Peter and Zamani, Alemeh and Kubíčková, Lucie and Dubový, Petr and Joukal, Marek},
article_location = {LONDON},
article_number = {1},
doi = {http://dx.doi.org/10.1186/s12987-020-00196-2},
keywords = {Choroid plexus; Blood-cerebrospinal fluid barrier; Inflammatory diseases; Neurodegenerative disease; Autoimmune disease; Stroke; Carcinoma},
language = {eng},
issn = {2045-8118},
journal = {FLUIDS AND BARRIERS OF THE CNS},
title = {Choroid plexus and the blood-cerebrospinal fluid barrier in disease},
url = {https://fluidsbarrierscns.biomedcentral.com/track/pdf/10.1186/s12987-020-00196-2},
volume = {17},
year = {2020}
}
TY - JOUR
ID - 1670502
AU - Solár, Peter - Zamani, Alemeh - Kubíčková, Lucie - Dubový, Petr - Joukal, Marek
PY - 2020
TI - Choroid plexus and the blood-cerebrospinal fluid barrier in disease
JF - FLUIDS AND BARRIERS OF THE CNS
VL - 17
IS - 1
SP - 1-29
EP - 1-29
PB - BMC
SN - 20458118
KW - Choroid plexus
KW - Blood-cerebrospinal fluid barrier
KW - Inflammatory diseases
KW - Neurodegenerative disease
KW - Autoimmune disease
KW - Stroke
KW - Carcinoma
UR - https://fluidsbarrierscns.biomedcentral.com/track/pdf/10.1186/s12987-020-00196-2
L2 - https://fluidsbarrierscns.biomedcentral.com/track/pdf/10.1186/s12987-020-00196-2
N2 - The choroid plexus (CP) forming the blood-cerebrospinal fluid (B-CSF) barrier is among the least studied structures of the central nervous system (CNS) despite its clinical importance. The CP is an epithelio-endothelial convolute comprising a highly vascularized stroma with fenestrated capillaries and a continuous lining of epithelial cells joined by apical tight junctions (TJs) that are crucial in forming the B-CSF barrier. Integrity of the CP is critical for maintaining brain homeostasis and B-CSF barrier permeability. Recent experimental and clinical research has uncovered the significance of the CP in the pathophysiology of various diseases affecting the CNS. The CP is involved in penetration of various pathogens into the CNS, as well as the development of neurodegenerative (e.g., Alzheimer ' s disease) and autoimmune diseases (e.g., multiple sclerosis). Moreover, the CP was shown to be important for restoring brain homeostasis following stroke and trauma. In addition, new diagnostic methods and treatment of CP papilloma and carcinoma have recently been developed. This review describes and summarizes the current state of knowledge with regard to the roles of the CP and B-CSF barrier in the pathophysiology of various types of CNS diseases and sets up the foundation for further avenues of research.
ER -
SOLÁR, Peter, Alemeh ZAMANI, Lucie KUBÍČKOVÁ, Petr DUBOVÝ a Marek JOUKAL. Choroid plexus and the blood-cerebrospinal fluid barrier in disease. \textit{FLUIDS AND BARRIERS OF THE CNS}. LONDON: BMC, roč.~17, č.~1, s.~1-29. ISSN~2045-8118. doi:10.1186/s12987-020-00196-2. 2020.
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