J 2020

Choroid plexus and the blood-cerebrospinal fluid barrier in disease

SOLÁR, Peter, Alemeh ZAMANI, Lucie KUBÍČKOVÁ, Petr DUBOVÝ, Marek JOUKAL et. al.

Basic information

Original name

Choroid plexus and the blood-cerebrospinal fluid barrier in disease

Authors

SOLÁR, Peter (703 Slovakia, belonging to the institution), Alemeh ZAMANI (364 Islamic Republic of Iran, belonging to the institution), Lucie KUBÍČKOVÁ (203 Czech Republic, belonging to the institution), Petr DUBOVÝ (203 Czech Republic, belonging to the institution) and Marek JOUKAL (203 Czech Republic, guarantor, belonging to the institution)

Edition

FLUIDS AND BARRIERS OF THE CNS, LONDON, BMC, 2020, 2045-8118

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 7.662

RIV identification code

RIV/00216224:14110/20:00116013

Organization unit

Faculty of Medicine

DOI

UT WoS

000533940400002

Keywords in English

Choroid plexus; Blood-cerebrospinal fluid barrier; Inflammatory diseases; Neurodegenerative disease; Autoimmune disease; Stroke; Carcinoma

Tags

Tags

International impact, Reviewed
Změněno: 23/2/2021 13:55, Mgr. Tereza Miškechová

Abstract

V originále

The choroid plexus (CP) forming the blood-cerebrospinal fluid (B-CSF) barrier is among the least studied structures of the central nervous system (CNS) despite its clinical importance. The CP is an epithelio-endothelial convolute comprising a highly vascularized stroma with fenestrated capillaries and a continuous lining of epithelial cells joined by apical tight junctions (TJs) that are crucial in forming the B-CSF barrier. Integrity of the CP is critical for maintaining brain homeostasis and B-CSF barrier permeability. Recent experimental and clinical research has uncovered the significance of the CP in the pathophysiology of various diseases affecting the CNS. The CP is involved in penetration of various pathogens into the CNS, as well as the development of neurodegenerative (e.g., Alzheimer ' s disease) and autoimmune diseases (e.g., multiple sclerosis). Moreover, the CP was shown to be important for restoring brain homeostasis following stroke and trauma. In addition, new diagnostic methods and treatment of CP papilloma and carcinoma have recently been developed. This review describes and summarizes the current state of knowledge with regard to the roles of the CP and B-CSF barrier in the pathophysiology of various types of CNS diseases and sets up the foundation for further avenues of research.

Links

EF16_027/0008360, research and development project
Name: Postdoc@MUNI
MUNI/A/0975/2019, interní kód MU
Name: Studium změn ve strukturách nervové soustavy po poškození
Investor: Masaryk University, Category A
MUNI/A/1086/2018, interní kód MU
Name: Reakce struktur nervové soustavy na poškození
Investor: Masaryk University, Category A
ROZV/23/LF14/2019, interní kód MU
Name: Elektrofyziologická a imunohistochemická studie změn podmíněných neurozánětem ve spinálních gangliích neasociovaných s poškozeným periferním nervem
Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects