The association of lorg-term outcome and biological sex in
patients with acute heart failure from different geographic
regions

J 2020

The association of lorg-term outcome and biological sex in patients with acute heart failure from different geographic regions

MOTIEJUNAITE, J., E. AKIYAMA, A. COHEN-SOLAL, A. P. MAGGIONI, C. MUELLER et. al.

Basic information

Original name

The association of lorg-term outcome and biological sex in patients with acute heart failure from different geographic regions

Authors

MOTIEJUNAITE, J. (440 Lithuania), E. AKIYAMA (392 Japan), A. COHEN-SOLAL (250 France), A. P. MAGGIONI (380 Italy), C. MUELLER (756 Switzerland), D. J. CHOI (178 Congo), A. KAVOLIUNIENE (440 Lithuania), J. CELUTKIENE (440 Lithuania), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), J. LASSUS (246 Finland), K. KAJIMOTO (392 Japan), N. SATO (392 Japan), O. MIRO (724 Spain), W. F. PEACOCK (840 United States of America), Y. MATSUE (392 Japan), A. A. VOORS (528 Netherlands), C. S. P. LAM (702 Singapore), J. A. EZEKOWITZ (124 Canada), A. AHMED (840 United States of America), G. C. FONAROW (840 United States of America), E. GAYAT (250 France), V. REGITZ-ZAGROSEK (276 Germany) and A. MEBAZAA (250 France, guarantor)

Edition

European heart journal, Oxford, Oxford University Press, 2020, 0195-668X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 29.983

RIV identification code

RIV/00216224:14110/20:00116018

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1093/eurheartj/ehaa071

UT WoS

000522664500012

Keywords in English

Acute heart failure; Gender; Biological sex; Mortality; Prognosis

Abstract

V originále

Aims Recent data from national registries suggest that acute heart failure (AHF) outcomes might vary in men and women, however, it is not known whether this observation is universal. The aim of this study was to evaluate the association of biological sex and 1-year all-cause mortality in patients with AHF in various regions of the world. Methods and Results We analysed several AHF cohorts including GREAT registry (22 523 patients, mostly from Europe and Asia) and OPTIMIZE-HF (26 376 patients from the USA). Clinical characteristics and medication use at discharge were collected. Hazard ratios (HRs) for 1-year mortality according to biological sex were calculated using a Cox proportional hazards regression model with adjustment for baseline characteristics (e.g. age, comorbidities, clinical and laboratory parameters at admission, Left ventricular ejection fraction). In the GREAT registry, women had a Lower risk of death in the year following AHF [HR 0.86 (0.79-0.94), P< 0.001 after adjustment]. This was mostly driven by northeast Asia [n=9135, HR 0.76 (0.67-0.87), P< 0.001], while no significant differences were seen in other countries. In the OPTIMIZE-HF registry, women also had a tower risk of 1-year death [HR 0.93 (0.89-0.97), P < 0.001]. In the GREAT registry, women were less often prescribed with a combination of angiotensin-converting enzyme inhibitors and beta-Mockers at discharge (50% vs. 57%, P = 0.001). Conclusion Globally women with AHF have a lower 1-year mortality and less evidenced-based treatment than men. Differences among countries need further investigation. Our findings merit consideration when designing future global clinical trials in AHF.

Citovat

MOTIEJUNAITE, J., E. AKIYAMA, A. COHEN-SOLAL, A. P. MAGGIONI, C. MUELLER, D. J. CHOI, A. KAVOLIUNIENE, J. CELUTKIENE, Jiří PAŘENICA, J. LASSUS, K. KAJIMOTO, N. SATO, O. MIRO, W. F. PEACOCK, Y. MATSUE, A. A. VOORS, C. S. P. LAM, J. A. EZEKOWITZ, A. AHMED, G. C. FONAROW, E. GAYAT, V. REGITZ-ZAGROSEK and A. MEBAZAA. The association of lorg-term outcome and biological sex in patients with acute heart failure from different geographic regions. European heart journal. Oxford: Oxford University Press, 2020, vol. 41, No 13, p. 1357-1364. ISSN 0195-668X. Available from: https://dx.doi.org/10.1093/eurheartj/ehaa071.

@article{1670596,
   author = {Motiejunaite, J. and Akiyama, E. and CohenandSolal, A. and Maggioni, A. P. and Mueller, C. and Choi, D. J. and Kavoliuniene, A. and Celutkiene, J. and Pařenica, Jiří and Lassus, J. and Kajimoto, K. and Sato, N. and Miro, O. and Peacock, W. F. and Matsue, Y. and Voors, A. A. and Lam, C. S. P. and Ezekowitz, J. A. and Ahmed, A. and Fonarow, G. C. and Gayat, E. and RegitzandZagrosek, V. and Mebazaa, A.},
   article_location = {Oxford},
   article_number = {13},
   doi = {http://dx.doi.org/10.1093/eurheartj/ehaa071},
   keywords = {Acute heart failure; Gender; Biological sex; Mortality; Prognosis},
   language = {eng},
   issn = {0195-668X},
   journal = {European heart journal},
   title = {The association of lorg-term outcome and biological sex in patients with acute heart failure from different geographic regions},
   url = {https://watermark.silverchair.com/ehaa071.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAs0wggLJBgkqhkiG9w0BBwagggK6MIICtgIBADCCAq8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMt6G9vzj7d05TE7lwAgEQgIICgKpdeCE-BOO_5Vlg9onFq07m_ofMivuOkzQg1HJg9rwdgz},
   volume = {41},
   year = {2020}
}

TY  - JOUR
ID  - 1670596
AU  - Motiejunaite, J. - Akiyama, E. - Cohen-Solal, A. - Maggioni, A. P. - Mueller, C. - Choi, D. J. - Kavoliuniene, A. - Celutkiene, J. - Pařenica, Jiří - Lassus, J. - Kajimoto, K. - Sato, N. - Miro, O. - Peacock, W. F. - Matsue, Y. - Voors, A. A. - Lam, C. S. P. - Ezekowitz, J. A. - Ahmed, A. - Fonarow, G. C. - Gayat, E. - Regitz-Zagrosek, V. - Mebazaa, A.
PY  - 2020
TI  - The association of lorg-term outcome and biological sex in patients with acute heart failure from different geographic regions
JF  - European heart journal
VL  - 41
IS  - 13
SP  - 1357-1364
EP  - 1357-1364
PB  - Oxford University Press
SN  - 0195668X
KW  - Acute heart failure
KW  - Gender
KW  - Biological sex
KW  - Mortality
KW  - Prognosis
UR  - https://watermark.silverchair.com/ehaa071.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAs0wggLJBgkqhkiG9w0BBwagggK6MIICtgIBADCCAq8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMt6G9vzj7d05TE7lwAgEQgIICgKpdeCE-BOO_5Vlg9onFq07m_ofMivuOkzQg1HJg9rwdgz
L2  - https://watermark.silverchair.com/ehaa071.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAs0wggLJBgkqhkiG9w0BBwagggK6MIICtgIBADCCAq8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMt6G9vzj7d05TE7lwAgEQgIICgKpdeCE-BOO_5Vlg9onFq07m_ofMivuOkzQg1HJg9rwdgz
N2  - Aims Recent data from national registries suggest that acute heart failure (AHF) outcomes might vary in men and women, however, it is not known whether this observation is universal. The aim of this study was to evaluate the association of biological sex and 1-year all-cause mortality in patients with AHF in various regions of the world. Methods and Results We analysed several AHF cohorts including GREAT registry (22 523 patients, mostly from Europe and Asia) and OPTIMIZE-HF (26 376 patients from the USA). Clinical characteristics and medication use at discharge were collected. Hazard ratios (HRs) for 1-year mortality according to biological sex were calculated using a Cox proportional hazards regression model with adjustment for baseline characteristics (e.g. age, comorbidities, clinical and laboratory parameters at admission, Left ventricular ejection fraction). In the GREAT registry, women had a Lower risk of death in the year following AHF [HR 0.86 (0.79-0.94), P< 0.001 after adjustment]. This was mostly driven by northeast Asia [n=9135, HR 0.76 (0.67-0.87), P< 0.001], while no significant differences were seen in other countries. In the OPTIMIZE-HF registry, women also had a tower risk of 1-year death [HR 0.93 (0.89-0.97), P < 0.001]. In the GREAT registry, women were less often prescribed with a combination of angiotensin-converting enzyme inhibitors and beta-Mockers at discharge (50% vs. 57%, P = 0.001). Conclusion Globally women with AHF have a lower 1-year mortality and less evidenced-based treatment than men. Differences among countries need further investigation. Our findings merit consideration when designing future global clinical trials in AHF.
ER  -

MOTIEJUNAITE, J., E. AKIYAMA, A. COHEN-SOLAL, A. P. MAGGIONI, C. MUELLER, D. J. CHOI, A. KAVOLIUNIENE, J. CELUTKIENE, Jiří PAŘENICA, J. LASSUS, K. KAJIMOTO, N. SATO, O. MIRO, W. F. PEACOCK, Y. MATSUE, A. A. VOORS, C. S. P. LAM, J. A. EZEKOWITZ, A. AHMED, G. C. FONAROW, E. GAYAT, V. REGITZ-ZAGROSEK and A. MEBAZAA. The association of lorg-term outcome and biological sex in patients with acute heart failure from different geographic regions. \textit{European heart journal}. Oxford: Oxford University Press, 2020, vol.~41, No~13, p.~1357-1364. ISSN~0195-668X. Available from: https://dx.doi.org/10.1093/eurheartj/ehaa071.

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