Lactobacilli-dominated cervical microbiota in women with
preterm prelabor rupture of membranes

J 2020

Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes

KACEROVSKY, Marian, Lenka PLISKOVA, Radka BOLEHOVSKA, Romana GERYCHOVÁ, Petr JANKŮ et. al.

Basic information

Original name

Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes

Authors

KACEROVSKY, Marian (203 Czech Republic, guarantor), Lenka PLISKOVA (203 Czech Republic), Radka BOLEHOVSKA (203 Czech Republic), Romana GERYCHOVÁ (203 Czech Republic, belonging to the institution), Petr JANKŮ (203 Czech Republic, belonging to the institution), Petr MATLAK (203 Czech Republic), Ondrej SIMETKA (203 Czech Republic), Tomas FAIST (203 Czech Republic), Jan MLS (203 Czech Republic), Petr VESCICIK (203 Czech Republic), Helena ZEMLICKOVA (203 Czech Republic), Bo JACOBSSON (752 Sweden) and Ivana MUSILOVA (203 Czech Republic)

Edition

Pediatric Research, New York, Nature Publishing Group, 2020, 0031-3998

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30209 Paediatrics

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.756

RIV identification code

RIV/00216224:14110/20:00116019

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41390-019-0692-1

UT WoS

000525281400027

Keywords in English

INTRAAMNIOTIC INFLAMMATION; PREMATURE RUPTURE; AMNIOTIC CAVITY; INTERLEUKIN-6; INVASION; FLUID

Abstract

V originále

Background To determine the association between microbial invasion of the amniotic cavity (MIAC) and the presence of Lactobacillus crispatus- or Lactobacillus iners-dominated cervical microbiota in pregnancies with preterm prelabor rupture of membrane. Next, to assess the relationship between the presence of L. crispatus- or L. iners-dominated cervical microbiota and short-term neonatal morbidity. Method A total of 311 women were included. Cervical samples were obtained using a Dacron polyester swab and amniotic fluid samples were obtained by transabdominal amniocentesis. Bacterial DNA, L. crispatus, and L. iners in the cervical samples were assessed by PCR. Cervical microbiota was assigned as L. crispatus- or L. iners-dominated when the relative abundance of L. crispatus or L. iners was >= 50% of the whole cervical microbiota, respectively. Results Women with MIAC showed a lower rate of L. crispatus-dominated cervical microbiota (21% vs. 39%; p = 0.003) than those without MIAC. Lactobacillus crispatus-dominated cervical microbiota was associated with a lower rate of early-onset sepsis (0% vs. 5%; p = 0.02). Conclusions The presence of L. crispatus-dominated cervical microbiota in women with preterm prelabor rupture of membrane was associated with a lower risk of intra-amniotic complications and subsequent development of early-onset sepsis of newborns.

Citovat

KACEROVSKY, Marian, Lenka PLISKOVA, Radka BOLEHOVSKA, Romana GERYCHOVÁ, Petr JANKŮ, Petr MATLAK, Ondrej SIMETKA, Tomas FAIST, Jan MLS, Petr VESCICIK, Helena ZEMLICKOVA, Bo JACOBSSON and Ivana MUSILOVA. Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes. Pediatric Research. New York: Nature Publishing Group, 2020, vol. 87, No 5, p. 952-960. ISSN 0031-3998. Available from: https://dx.doi.org/10.1038/s41390-019-0692-1.

@article{1670597,
   author = {Kacerovsky, Marian and Pliskova, Lenka and Bolehovska, Radka and Gerychová, Romana and Janků, Petr and Matlak, Petr and Simetka, Ondrej and Faist, Tomas and Mls, Jan and Vescicik, Petr and Zemlickova, Helena and Jacobsson, Bo and Musilova, Ivana},
   article_location = {New York},
   article_number = {5},
   doi = {http://dx.doi.org/10.1038/s41390-019-0692-1},
   keywords = {INTRAAMNIOTIC INFLAMMATION; PREMATURE RUPTURE; AMNIOTIC CAVITY; INTERLEUKIN-6; INVASION; FLUID},
   language = {eng},
   issn = {0031-3998},
   journal = {Pediatric Research},
   title = {Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes},
   url = {https://www.nature.com/articles/s41390-019-0692-1},
   volume = {87},
   year = {2020}
}

TY  - JOUR
ID  - 1670597
AU  - Kacerovsky, Marian - Pliskova, Lenka - Bolehovska, Radka - Gerychová, Romana - Janků, Petr - Matlak, Petr - Simetka, Ondrej - Faist, Tomas - Mls, Jan - Vescicik, Petr - Zemlickova, Helena - Jacobsson, Bo - Musilova, Ivana
PY  - 2020
TI  - Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes
JF  - Pediatric Research
VL  - 87
IS  - 5
SP  - 952-960
EP  - 952-960
PB  - Nature Publishing Group
SN  - 00313998
KW  - INTRAAMNIOTIC INFLAMMATION
KW  - PREMATURE RUPTURE
KW  - AMNIOTIC CAVITY
KW  - INTERLEUKIN-6
KW  - INVASION
KW  - FLUID
UR  - https://www.nature.com/articles/s41390-019-0692-1
L2  - https://www.nature.com/articles/s41390-019-0692-1
N2  - Background To determine the association between microbial invasion of the amniotic cavity (MIAC) and the presence of Lactobacillus crispatus- or Lactobacillus iners-dominated cervical microbiota in pregnancies with preterm prelabor rupture of membrane. Next, to assess the relationship between the presence of L. crispatus- or L. iners-dominated cervical microbiota and short-term neonatal morbidity. Method A total of 311 women were included. Cervical samples were obtained using a Dacron polyester swab and amniotic fluid samples were obtained by transabdominal amniocentesis. Bacterial DNA, L. crispatus, and L. iners in the cervical samples were assessed by PCR. Cervical microbiota was assigned as L. crispatus- or L. iners-dominated when the relative abundance of L. crispatus or L. iners was >= 50% of the whole cervical microbiota, respectively. Results Women with MIAC showed a lower rate of L. crispatus-dominated cervical microbiota (21% vs. 39%; p = 0.003) than those without MIAC. Lactobacillus crispatus-dominated cervical microbiota was associated with a lower rate of early-onset sepsis (0% vs. 5%; p = 0.02). Conclusions The presence of L. crispatus-dominated cervical microbiota in women with preterm prelabor rupture of membrane was associated with a lower risk of intra-amniotic complications and subsequent development of early-onset sepsis of newborns.
ER  -

KACEROVSKY, Marian, Lenka PLISKOVA, Radka BOLEHOVSKA, Romana GERYCHOVÁ, Petr JANKŮ, Petr MATLAK, Ondrej SIMETKA, Tomas FAIST, Jan MLS, Petr VESCICIK, Helena ZEMLICKOVA, Bo JACOBSSON and Ivana MUSILOVA. Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes. \textit{Pediatric Research}. New York: Nature Publishing Group, 2020, vol.~87, No~5, p.~952-960. ISSN~0031-3998. Available from: https://dx.doi.org/10.1038/s41390-019-0692-1.

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