J 2020

Impact of Decreased Transmural Conduction Velocity on the Function of the Human Left Ventricle: A Simulation Study

VAVERKA, Jiri, Jiří MOUDR, Petr LOKAJ, Jiri BURSA, Michal PÁSEK et. al.

Basic information

Original name

Impact of Decreased Transmural Conduction Velocity on the Function of the Human Left Ventricle: A Simulation Study

Authors

VAVERKA, Jiri (203 Czech Republic), Jiří MOUDR (203 Czech Republic, belonging to the institution), Petr LOKAJ (203 Czech Republic), Jiri BURSA (203 Czech Republic) and Michal PÁSEK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Biomed Research International, London, Hindawi Publishing Corporation, 2020, 2314-6133

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.411

RIV identification code

RIV/00216224:14110/20:00116020

Organization unit

Faculty of Medicine

DOI

UT WoS

000528680300003

Keywords in English

HEART; GENE; MYOCARDIUM; MUTATIONS; CHILDREN; DURATION; MODEL

Tags

Tags

International impact, Reviewed
Změněno: 17/7/2020 08:16, Mgr. Tereza Miškechová

Abstract

V originále

This study investigates the impact of reduced transmural conduction velocity (TCV) on output parameters of the human heart. In a healthy heart, the TCV contributes to synchronization of the onset of contraction in individual layers of the left ventricle (LV). However, it is unclear whether the clinically observed decrease of TCV contributes significantly to a reduction of LV contractility. The applied three-dimensional finite element model of isovolumic contraction of the human LV incorporates transmural gradients in electromechanical delay and myocyte shortening velocity and evaluates the impact of TCV reduction on pressure rise (namely, (dP/dt)(max)) and on isovolumic contraction duration (IVCD) in a healthy LV. The model outputs are further exploited in the lumped "Windkessel" model of the human cardiovascular system (based on electrohydrodynamic analogy of respective differential equations) to simulate the impact of changes of (dP/dt)(max) and IVCD on chosen systemic parameters (ejection fraction, LV power, cardiac output, and blood pressure). The simulations have shown that a 50% decrease in TCV prolongs substantially the isovolumic contraction, decelerates slightly the LV pressure rise, increases the LV energy consumption, and reduces the LV power. These negative effects increase progressively with further reduction of TCV. In conclusion, these results suggest that the pumping efficacy of the human LV decreases with lower TCV due to a higher energy consumption and lower LV power. Although the changes induced by the clinically relevant reduction of TCV are not critical for a healthy heart, they may represent an important factor limiting the heart function under disease conditions.