Impact of Decreased Transmural Conduction Velocity on the Function of the Human Left Ventricle: A Simulation Study

VAVERKA, Jiri, Jiří MOUDR, Petr LOKAJ, Jiri BURSA and Michal PÁSEK. Impact of Decreased Transmural Conduction Velocity on the Function of the Human Left Ventricle: A Simulation Study. Biomed Research International. London: Hindawi Publishing Corporation, 2020, vol. 2020, APR 2020, p. 1-11. ISSN 2314-6133. Available from: https://dx.doi.org/10.1155/2020/2867865.

Basic information

• Original name: Impact of Decreased Transmural Conduction Velocity on the Function of the Human Left Ventricle: A Simulation Study
• Authors: VAVERKA, Jiri (203 Czech Republic), Jiří MOUDR (203 Czech Republic, belonging to the institution), Petr LOKAJ (203 Czech Republic), Jiri BURSA (203 Czech Republic) and Michal PÁSEK (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Biomed Research International, London, Hindawi Publishing Corporation, 2020, 2314-6133.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30105 Physiology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.411
• RIV identification code: RIV/00216224:14110/20:00116020
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1155/2020/2867865
• UT WoS: 000528680300003
• Keywords in English: HEART; GENE; MYOCARDIUM; MUTATIONS; CHILDREN; DURATION; MODEL
• Tags: 14110515, rivok
• Tags: International impact, Reviewed

Abstract

This study investigates the impact of reduced transmural conduction velocity (TCV) on output parameters of the human heart. In a healthy heart, the TCV contributes to synchronization of the onset of contraction in individual layers of the left ventricle (LV). However, it is unclear whether the clinically observed decrease of TCV contributes significantly to a reduction of LV contractility. The applied three-dimensional finite element model of isovolumic contraction of the human LV incorporates transmural gradients in electromechanical delay and myocyte shortening velocity and evaluates the impact of TCV reduction on pressure rise (namely, (dP/dt)(max)) and on isovolumic contraction duration (IVCD) in a healthy LV. The model outputs are further exploited in the lumped "Windkessel" model of the human cardiovascular system (based on electrohydrodynamic analogy of respective differential equations) to simulate the impact of changes of (dP/dt)(max) and IVCD on chosen systemic parameters (ejection fraction, LV power, cardiac output, and blood pressure). The simulations have shown that a 50% decrease in TCV prolongs substantially the isovolumic contraction, decelerates slightly the LV pressure rise, increases the LV energy consumption, and reduces the LV power. These negative effects increase progressively with further reduction of TCV. In conclusion, these results suggest that the pumping efficacy of the human LV decreases with lower TCV due to a higher energy consumption and lower LV power. Although the changes induced by the clinically relevant reduction of TCV are not critical for a healthy heart, they may represent an important factor limiting the heart function under disease conditions.