Cold atmospheric pressure plasma: simple and efficient strategy
for preparation of poly(2-oxazoline)-based coatings designed
for biomedical applications

J 2020

Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications

ŠRÁMKOVÁ, Petra, Anna ZAHORANOVÁ, Jakub KELAR, Zlata KELAR TUČEKOVÁ, Monika STUPAVSKÁ et. al.

Basic information

Original name

Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications

Authors

ŠRÁMKOVÁ, Petra (703 Slovakia, guarantor, belonging to the institution), Anna ZAHORANOVÁ (703 Slovakia), Jakub KELAR (203 Czech Republic, belonging to the institution), Zlata KELAR TUČEKOVÁ (703 Slovakia, belonging to the institution), Monika STUPAVSKÁ (703 Slovakia, belonging to the institution), Richard KRUMPOLEC (703 Slovakia, belonging to the institution), Jana JURMANOVÁ (203 Czech Republic, belonging to the institution), Dušan KOVÁČIK (703 Slovakia, belonging to the institution) and Mirko ČERNÁK (703 Slovakia, belonging to the institution)

Edition

Scientific Reports, London, Nature Publishing Group, 2020, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10305 Fluids and plasma physics

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.379

RIV identification code

RIV/00216224:14310/20:00116039

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1038/s41598-020-66423-w

UT WoS

000559959500029

Keywords (in Czech)

2-oxazolín; tenké vrstvy; studené plazma; DCSBD; bunková adheze, bioaplikace

Keywords in English

2-oxazoline; thin layers; cold plasma; DCSBD; cell adhesion; bioapplications

Abstract

V originále

Poly(2-oxazolines) (POx) are an attractive material of choice for biocompatible and bioactive coatings in medical applications. To prepare POx coatings, the plasma polymerization represents a fast and facile approach that is surface-independent. However, unfavorable factors of this method such as using the low-pressure regimes and noble gases, or poor control over the resulting surface chemistry limit its utilization. Here, we propose to overcome these drawbacks by using well-defined POx-based copolymers prepared by living cationic polymerization as a starting material. Chemically inert polytetrafluoroethylene (PTFE) is selected as a substrate due to its beneficial features for medical applications. The deposited POx layer is additionally post-treated by non-equilibrium plasma generated at atmospheric pressure. For this purpose, diffuse coplanar surface barrier discharge (DCSBD) is used as a source of “cold” homogeneous plasma, as it is operating at atmospheric pressure even in ambient air. Prepared POx coatings possess hydrophilic nature with an achieved water contact angle of 60°, which is noticeably lower in comparison to the initial value of 106° for raw PTFE. Moreover, the increased fibroblasts adhesion in comparison to raw PTFE is achieved, and the physical and biological properties of the POx-modified surfaces remain stable for 30 days.

Links

EF16_027/0008360, research and development project

Name: Postdoc@MUNI

90110, large research infrastructures

Name: CzechNanoLab

Citovat

ŠRÁMKOVÁ, Petra, Anna ZAHORANOVÁ, Jakub KELAR, Zlata KELAR TUČEKOVÁ, Monika STUPAVSKÁ, Richard KRUMPOLEC, Jana JURMANOVÁ, Dušan KOVÁČIK and Mirko ČERNÁK. Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications. Scientific Reports. London: Nature Publishing Group, 2020, vol. 10, No 1, p. 1-13. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-66423-w.

@article{1671141,
   author = {Šrámková, Petra and Zahoranová, Anna and Kelar, Jakub and Kelar Tučeková, Zlata and Stupavská, Monika and Krumpolec, Richard and Jurmanová, Jana and Kováčik, Dušan and Černák, Mirko},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-020-66423-w},
   keywords = {2-oxazoline; thin layers; cold plasma; DCSBD; cell adhesion; bioapplications},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications},
   url = {https://www.nature.com/articles/s41598-020-66423-w},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1671141
AU  - Šrámková, Petra - Zahoranová, Anna - Kelar, Jakub - Kelar Tučeková, Zlata - Stupavská, Monika - Krumpolec, Richard - Jurmanová, Jana - Kováčik, Dušan - Černák, Mirko
PY  - 2020
TI  - Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications
JF  - Scientific Reports
VL  - 10
IS  - 1
SP  - 1-13
EP  - 1-13
PB  - Nature Publishing Group
SN  - 20452322
KW  - 2-oxazoline
KW  - thin layers
KW  - cold plasma
KW  - DCSBD
KW  - cell adhesion
KW  - bioapplications
UR  - https://www.nature.com/articles/s41598-020-66423-w
L2  - https://www.nature.com/articles/s41598-020-66423-w
N2  - Poly(2-oxazolines) (POx) are an attractive material of choice for biocompatible and bioactive coatings in medical applications. To prepare POx coatings, the plasma polymerization represents a fast and facile approach that is surface-independent. However, unfavorable factors of this method such as using the low-pressure regimes and noble gases, or poor control over the resulting surface chemistry limit its utilization. Here, we propose to overcome these drawbacks by using well-defined POx-based copolymers prepared by living cationic polymerization as a starting material. Chemically inert polytetrafluoroethylene (PTFE) is selected as a substrate due to its beneficial features for medical applications. The deposited POx layer is additionally post-treated by non-equilibrium plasma generated at atmospheric pressure. For this purpose, diffuse coplanar surface barrier discharge (DCSBD) is used as a source of “cold” homogeneous plasma, as it is operating at atmospheric pressure even in ambient air. Prepared POx coatings possess hydrophilic nature with an achieved water contact angle of 60°, which is noticeably lower in comparison to the initial value of 106° for raw PTFE. Moreover, the increased fibroblasts adhesion in comparison to raw PTFE is achieved, and the physical and biological properties of the POx-modified surfaces remain stable for 30 days.
ER  -

ŠRÁMKOVÁ, Petra, Anna ZAHORANOVÁ, Jakub KELAR, Zlata KELAR TUČEKOVÁ, Monika STUPAVSKÁ, Richard KRUMPOLEC, Jana JURMANOVÁ, Dušan KOVÁČIK and Mirko ČERNÁK. Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications. \textit{Scientific Reports}. London: Nature Publishing Group, 2020, vol.~10, No~1, p.~1-13. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-66423-w.

Detailed Information on Publication Record