Micrometastases in Sentinel Lymph Nodes Represent a Significant
Negative Prognostic Factor in Early-Stage Cervical Cancer: A
Single-Institutional Retrospective Cohort Study

J 2020

Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study

KOCIAN, Roman, Jiri SLAMA, Daniela FISCHEROVA, Anna GERMANOVA, Andrea BURGETOVA et. al.

Basic information

Original name

Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study

Authors

KOCIAN, Roman (203 Czech Republic), Jiri SLAMA (203 Czech Republic), Daniela FISCHEROVA (203 Czech Republic), Anna GERMANOVA (203 Czech Republic), Andrea BURGETOVA (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Pavel DUNDR, Kristyna NEMEJCOVA (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Silvie SEBESTOVA (203 Czech Republic), Filip FRUHAUF (203 Czech Republic), Lukas DOSTALEK (203 Czech Republic), Tereza BALLASCHOVA (203 Czech Republic) and David CIBULA (203 Czech Republic, guarantor)

Edition

Cancers, BASEL, MDPI, 2020, 2072-6694

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.639

RIV identification code

RIV/00216224:14110/20:00116113

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/cancers12061438

UT WoS

000549262500001

Keywords in English

micrometastasis; isolated tumor cells; sentinel lymph node; cervical cancer; pathological ultrastaging; prognostic parameters; risk of recurrence

Abstract

V originále

The data on the prognostic significance of low volume metastases in lymph nodes (LN) are inconsistent. The aim of this study was to retrospectively analyze the outcome of a large group of patients treated with sentinel lymph node (SLN) biopsy at a single referral center. Patients with cervical cancer, stage T1a-T2b, common tumor types, negative LN on preoperative staging, treated by primary surgery between 01/2007 and 12/2016, with at least unilateral SLN detection were included. Patients with abandoned radical surgery due to intraoperative SLN positivity detected by frozen section were excluded. All SLNs were postoperatively processed by an intensive protocol for pathological ultrastaging. Altogether, 226 patients were analyzed. Positive LN were detected in 38 (17%) cases; macrometastases (MAC), micrometastases (MIC), isolated tumor cells (ITC) in 14, 16, and 8 patients. With the median follow-up of 65 months, 22 recurrences occurred. Disease-free survival (DFS) reached 90% in the whole group, 93% in LN-negative cases, 89% in cases with MAC, 69% with MIC, and 87% with ITC. The presence of MIC in SLN was associated with significantly decreased DFS and OS. Patients with MIC and MAC should be managed similarly, and SLN ultrastaging should become an integral part of the management of patients with early-stage cervical cancer.

Citovat

KOCIAN, Roman, Jiri SLAMA, Daniela FISCHEROVA, Anna GERMANOVA, Andrea BURGETOVA, Ladislav DUŠEK, Pavel DUNDR, Kristyna NEMEJCOVA, Jiří JARKOVSKÝ, Silvie SEBESTOVA, Filip FRUHAUF, Lukas DOSTALEK, Tereza BALLASCHOVA and David CIBULA. Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study. Cancers. BASEL: MDPI, 2020, vol. 12, No 6, p. 1-14. ISSN 2072-6694. Available from: https://dx.doi.org/10.3390/cancers12061438.

@article{1672840,
   author = {Kocian, Roman and Slama, Jiri and Fischerova, Daniela and Germanova, Anna and Burgetova, Andrea and Dušek, Ladislav and Dundr, Pavel and Nemejcova, Kristyna and Jarkovský, Jiří and Sebestova, Silvie and Fruhauf, Filip and Dostalek, Lukas and Ballaschova, Tereza and Cibula, David},
   article_location = {BASEL},
   article_number = {6},
   doi = {http://dx.doi.org/10.3390/cancers12061438},
   keywords = {micrometastasis; isolated tumor cells; sentinel lymph node; cervical cancer; pathological ultrastaging; prognostic parameters; risk of recurrence},
   language = {eng},
   issn = {2072-6694},
   journal = {Cancers},
   title = {Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study},
   url = {https://www.mdpi.com/2072-6694/12/6/1438},
   volume = {12},
   year = {2020}
}

TY  - JOUR
ID  - 1672840
AU  - Kocian, Roman - Slama, Jiri - Fischerova, Daniela - Germanova, Anna - Burgetova, Andrea - Dušek, Ladislav - Dundr, Pavel - Nemejcova, Kristyna - Jarkovský, Jiří - Sebestova, Silvie - Fruhauf, Filip - Dostalek, Lukas - Ballaschova, Tereza - Cibula, David
PY  - 2020
TI  - Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study
JF  - Cancers
VL  - 12
IS  - 6
SP  - 1-14
EP  - 1-14
PB  - MDPI
SN  - 20726694
KW  - micrometastasis
KW  - isolated tumor cells
KW  - sentinel lymph node
KW  - cervical cancer
KW  - pathological ultrastaging
KW  - prognostic parameters
KW  - risk of recurrence
UR  - https://www.mdpi.com/2072-6694/12/6/1438
L2  - https://www.mdpi.com/2072-6694/12/6/1438
N2  - The data on the prognostic significance of low volume metastases in lymph nodes (LN) are inconsistent. The aim of this study was to retrospectively analyze the outcome of a large group of patients treated with sentinel lymph node (SLN) biopsy at a single referral center. Patients with cervical cancer, stage T1a-T2b, common tumor types, negative LN on preoperative staging, treated by primary surgery between 01/2007 and 12/2016, with at least unilateral SLN detection were included. Patients with abandoned radical surgery due to intraoperative SLN positivity detected by frozen section were excluded. All SLNs were postoperatively processed by an intensive protocol for pathological ultrastaging. Altogether, 226 patients were analyzed. Positive LN were detected in 38 (17%) cases; macrometastases (MAC), micrometastases (MIC), isolated tumor cells (ITC) in 14, 16, and 8 patients. With the median follow-up of 65 months, 22 recurrences occurred. Disease-free survival (DFS) reached 90% in the whole group, 93% in LN-negative cases, 89% in cases with MAC, 69% with MIC, and 87% with ITC. The presence of MIC in SLN was associated with significantly decreased DFS and OS. Patients with MIC and MAC should be managed similarly, and SLN ultrastaging should become an integral part of the management of patients with early-stage cervical cancer.
ER  -

KOCIAN, Roman, Jiri SLAMA, Daniela FISCHEROVA, Anna GERMANOVA, Andrea BURGETOVA, Ladislav DUŠEK, Pavel DUNDR, Kristyna NEMEJCOVA, Jiří JARKOVSKÝ, Silvie SEBESTOVA, Filip FRUHAUF, Lukas DOSTALEK, Tereza BALLASCHOVA and David CIBULA. Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study. \textit{Cancers}. BASEL: MDPI, 2020, vol.~12, No~6, p.~1-14. ISSN~2072-6694. Available from: https://dx.doi.org/10.3390/cancers12061438.

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