Other formats:
BibTeX
LaTeX
RIS
@article{1672840, author = {Kocian, Roman and Slama, Jiri and Fischerova, Daniela and Germanova, Anna and Burgetova, Andrea and Dušek, Ladislav and Dundr, Pavel and Nemejcova, Kristyna and Jarkovský, Jiří and Sebestova, Silvie and Fruhauf, Filip and Dostalek, Lukas and Ballaschova, Tereza and Cibula, David}, article_location = {BASEL}, article_number = {6}, doi = {http://dx.doi.org/10.3390/cancers12061438}, keywords = {micrometastasis; isolated tumor cells; sentinel lymph node; cervical cancer; pathological ultrastaging; prognostic parameters; risk of recurrence}, language = {eng}, issn = {2072-6694}, journal = {Cancers}, title = {Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study}, url = {https://www.mdpi.com/2072-6694/12/6/1438}, volume = {12}, year = {2020} }
TY - JOUR ID - 1672840 AU - Kocian, Roman - Slama, Jiri - Fischerova, Daniela - Germanova, Anna - Burgetova, Andrea - Dušek, Ladislav - Dundr, Pavel - Nemejcova, Kristyna - Jarkovský, Jiří - Sebestova, Silvie - Fruhauf, Filip - Dostalek, Lukas - Ballaschova, Tereza - Cibula, David PY - 2020 TI - Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study JF - Cancers VL - 12 IS - 6 SP - 1-14 EP - 1-14 PB - MDPI SN - 20726694 KW - micrometastasis KW - isolated tumor cells KW - sentinel lymph node KW - cervical cancer KW - pathological ultrastaging KW - prognostic parameters KW - risk of recurrence UR - https://www.mdpi.com/2072-6694/12/6/1438 L2 - https://www.mdpi.com/2072-6694/12/6/1438 N2 - The data on the prognostic significance of low volume metastases in lymph nodes (LN) are inconsistent. The aim of this study was to retrospectively analyze the outcome of a large group of patients treated with sentinel lymph node (SLN) biopsy at a single referral center. Patients with cervical cancer, stage T1a-T2b, common tumor types, negative LN on preoperative staging, treated by primary surgery between 01/2007 and 12/2016, with at least unilateral SLN detection were included. Patients with abandoned radical surgery due to intraoperative SLN positivity detected by frozen section were excluded. All SLNs were postoperatively processed by an intensive protocol for pathological ultrastaging. Altogether, 226 patients were analyzed. Positive LN were detected in 38 (17%) cases; macrometastases (MAC), micrometastases (MIC), isolated tumor cells (ITC) in 14, 16, and 8 patients. With the median follow-up of 65 months, 22 recurrences occurred. Disease-free survival (DFS) reached 90% in the whole group, 93% in LN-negative cases, 89% in cases with MAC, 69% with MIC, and 87% with ITC. The presence of MIC in SLN was associated with significantly decreased DFS and OS. Patients with MIC and MAC should be managed similarly, and SLN ultrastaging should become an integral part of the management of patients with early-stage cervical cancer. ER -
KOCIAN, Roman, Jiri SLAMA, Daniela FISCHEROVA, Anna GERMANOVA, Andrea BURGETOVA, Ladislav DUŠEK, Pavel DUNDR, Kristyna NEMEJCOVA, Jiří JARKOVSKÝ, Silvie SEBESTOVA, Filip FRUHAUF, Lukas DOSTALEK, Tereza BALLASCHOVA and David CIBULA. Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study. \textit{Cancers}. BASEL: MDPI, 2020, vol.~12, No~6, p.~1-14. ISSN~2072-6694. Available from: https://dx.doi.org/10.3390/cancers12061438.
|