| GOKBUGET, N., H. DOMBRET, S. GIEBEL, M. BRUGGEMANN, Michael DOUBEK, R. FOA, D. HOELZER, C. KIM, G. MARTINELLI, E. PAROVICHNIKOVA, J.M. RIBERA, M. SCHOONEN, C. TUGLUS, G. ZUGMAIER and R. BASSAN. Blinatumomab vs historic standard-of-care treatment for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukaemia. European Journal of Haematology. Hoboken: Wiley-Blackwell, 2020, vol. 104, No 4, p. 299-309. ISSN 0902-4441. Available from: https://dx.doi.org/10.1111/ejh.13375. |
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@article{1673039,
author = {Gokbuget, N. and Dombret, H. and Giebel, S. and Bruggemann, M. and Doubek, Michael and Foa, R. and Hoelzer, D. and Kim, C. and Martinelli, G. and Parovichnikova, E. and Ribera, J.M. and Schoonen, M. and Tuglus, C. and Zugmaier, G. and Bassan, R.},
article_location = {Hoboken},
article_number = {4},
doi = {http://dx.doi.org/10.1111/ejh.13375},
keywords = {acute lymphoblastic leukaemia; clinical trials},
language = {eng},
issn = {0902-4441},
journal = {European Journal of Haematology},
title = {Blinatumomab vs historic standard-of-care treatment for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukaemia},
url = {https://onlinelibrary.wiley.com/doi/full/10.1111/ejh.13375},
volume = {104},
year = {2020}
}
TY - JOUR
ID - 1673039
AU - Gokbuget, N. - Dombret, H. - Giebel, S. - Bruggemann, M. - Doubek, Michael - Foa, R. - Hoelzer, D. - Kim, C. - Martinelli, G. - Parovichnikova, E. - Ribera, J.M. - Schoonen, M. - Tuglus, C. - Zugmaier, G. - Bassan, R.
PY - 2020
TI - Blinatumomab vs historic standard-of-care treatment for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukaemia
JF - European Journal of Haematology
VL - 104
IS - 4
SP - 299-309
EP - 299-309
PB - Wiley-Blackwell
SN - 09024441
KW - acute lymphoblastic leukaemia
KW - clinical trials
UR - https://onlinelibrary.wiley.com/doi/full/10.1111/ejh.13375
L2 - https://onlinelibrary.wiley.com/doi/full/10.1111/ejh.13375
N2 - Objectives Survival outcomes from a single-arm phase 2 blinatumomab study in patients with minimal residual disease (MRD)-positive B-cell precursor (BCP)-acute lymphoblastic leukaemia (ALL) were compared with those receiving standard of care (SOC) in a historic data set. Methods The primary analysis comprised adult Philadelphia chromosome (Ph)-negative patients in first complete haematologic remission (MRD >= 10(-3)). Relapse-free survival (RFS) and overall survival (OS) were compared between blinatumomab- and SOC-treatment groups. Baseline differences between groups were adjusted by propensity scores. Results The primary analysis included 73 and 182 patients from the blinatumomab and historic data sets, respectively. When weighted by age to the blinatumomab-treatment group, median RFS was 7.8 months and median OS was 25.9 months in the SOC-treated group. In the blinatumomab study, median RFS was 35.2 months; median OS was not evaluable. Propensity score weighting achieved balance with seven baseline prognostic factors. With adjustment for haematopoietic stem cell transplantation (HSCT) status, a 50% reduction in risk of relapse or death was observed with blinatumomab vs SOC. Median RFS, unadjusted for HSCT status, was 35.2 months with blinatumomab and 8.3 months with SOC. Conclusions These analyses suggest that blinatumomab improves RFS, and possibly OS, in adults with MRD-positive Ph-negative BCP-ALL vs SOC.
ER -
GOKBUGET, N., H. DOMBRET, S. GIEBEL, M. BRUGGEMANN, Michael DOUBEK, R. FOA, D. HOELZER, C. KIM, G. MARTINELLI, E. PAROVICHNIKOVA, J.M. RIBERA, M. SCHOONEN, C. TUGLUS, G. ZUGMAIER and R. BASSAN. Blinatumomab vs historic standard-of-care treatment for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukaemia. \textit{European Journal of Haematology}. Hoboken: Wiley-Blackwell, 2020, vol.~104, No~4, p.~299-309. ISSN~0902-4441. Available from: https://dx.doi.org/10.1111/ejh.13375.
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